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1. (WO2007016622) GEL COMPOSITION FOR INHIBITING CELLULAR ADHESION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/016622    International Application No.:    PCT/US2006/030082
Publication Date: 08.02.2007 International Filing Date: 02.08.2006
Chapter 2 Demand Filed:    18.07.2007    
IPC:
A61L 31/04 (2006.01), A61L 31/16 (2006.01)
Applicants: WRIGHT MEDICAL TECHNOLODY, INC. [US/US]; 5677 Airline Road, Arlington, TN 38002-9501 (US) (For All Designated States Except US).
ZONG, Steven [US/US]; (US) (For US Only).
LO, Hungnan [US/US]; (US) (For US Only)
Inventors: ZONG, Steven; (US).
LO, Hungnan; (US)
Agent: SENTILLES, Shawn, D.; WRIGHT MEDICAL TECHNOLOGY, INC., 5677 Airline Road, Arlington, TN 38002-9501 (US).
CAGLE, Ryan, W.; Alston & Bird LLP, Bank of America Plaza, 101 south Tryon Street, Suite 4000, Charlotte, NC 28280-4000 (US)
Priority Data:
60/704,659 02.08.2005 US
11/461,800 02.08.2006 US
Title (EN) GEL COMPOSITION FOR INHIBITING CELLULAR ADHESION
(FR) COMPOSITION DE GELS INHIBITRICE DE L'ADHESION CELLULAIRE
Abstract: front page image
(EN)The invention includes compositions for inhibiting cellular adhesion, methods of preparation of such compositions, and methods for preventing cell adhesion at a surgical site comprising application of such compositions. The compositions generally comprise a cellular adhesion inhibitory agent, such as dextran sulfate, and a crosslinked hydrogel matrix, preferentially physically entrapping the adhesion inhibitory agent. The hydrogel matrix can include a first gel component, such as an electrophilically functionalized polyethylene glycol polymer, and at least one additional gel component, preferably nucleophilically functionalized, and preferentially selected from the group consisting of polyethylene glycol polymers, polypeptides, and polysaccharides. The compositions are useful for delivering the cellular adhesion inhibitory agent to a site in need of adhesion inhibition and providing either immediate or metered delivery of the inhibitory agent.
(FR)L'invention porte sur des compositions de gels inhibitrices de l'adhésion cellulaire, et sur des méthodes de prévention de l'adhésion cellulaire dans des sites chirurgicaux par application de telles compositions. Lesdites compositions comportent d'une manière générale un agent inhibiteur de l'adhésion cellulaire tel que du sulfate de dextran et une matrice d'hydrogels réticulés enrobant de préférence l'agent inhibiteur. La matrice d'hydrogel peut comporter un premier gel tel qu'un polymère de polyéthylène glycol rendu électrophile, et au moins un deuxième gel de préférence rendu nucléophile, et de préférence sélectionné parmi des polymères de polyéthylène glycol, des polypeptides, et des polysaccharides. Lesdites compositions servent à délivrer immédiatement ou de manière régulée l'agent inhibiteur d'adhésion cellulaire à un site le nécessitant.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)