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1. (WO2007016423) METHOD FOR ENANTIOSELECTIVE HYDROGENATION OF CHROMENES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/016423    International Application No.:    PCT/US2006/029589
Publication Date: 08.02.2007 International Filing Date: 01.08.2006
IPC:
C07D 311/00 (2006.01), C07D 231/02 (2006.01), C07F 15/00 (2006.01)
Applicants: GIRINDUS AMERICA INC. [US/US]; 8560 Reading Road, Cincinnati, OH 45215 (US) (For All Designated States Except US).
CHILDREN'S HOSPITAL MEDICAL CENTER [US/US]; 3333 Burnet Avenue, Cincinnati, OH 45229 (US) (For All Designated States Except US).
SETCHELL, Kenneth David Reginald [GB/US]; (US) (For US Only).
SOROKIN, Victor, Dmitrievich [US/US]; (US) (For US Only)
Inventors: SETCHELL, Kenneth David Reginald; (US).
SOROKIN, Victor, Dmitrievich; (US)
Agent: NESBITT, Daniel, F.; HASSE & NESBITT LLC, 8837 Chapel Square Drive, Suite C, Cincinnati, OH 45249 (US)
Priority Data:
11/194,280 01.08.2005 US
Title (EN) METHOD FOR ENANTIOSELECTIVE HYDROGENATION OF CHROMENES
(FR) PROCEDE D'HYDROGENATION ENANTIOSELECTIVE DE CHROMENES
Abstract: front page image
(EN)A method for preparing an enantiomeric chromane, by asymmetrically hydrogenating a chromene compound in the presence of an Ir catalyst having a chiral ligand. The method includes the enantioselective preparation of enantiomeric equol. A preferred Ir catalyst has a chiral phosphineoxazoline ligand. Enantiomeric chromanes of high stereoselective purity can be obtained.
(FR)L'invention porte sur un procédé de préparation d'un chromane énantiomère par hydrogénation asymétrique d'un composé chromène en présence d'un catalyseur Ir possédant un ligand chiral. Le procédé comprend la préparation énantiosélective d'équol énantiomère. Un catalyseur Ir préféré possède un ligand de phosphineoxazoline chiral. Il est ainsi possible d'obtenir des chromanes énantiomères de haute pureté stéréosélective.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)