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1. (WO2007016361) NOVEL PHARMACEUTICAL COMPOUNDS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/016361    International Application No.:    PCT/US2006/029461
Publication Date: 08.02.2007 International Filing Date: 28.07.2006
Chapter 2 Demand Filed:    28.02.2007    
IPC:
A01N 43/52 (2006.01), A61K 31/415 (2006.01)
Applicants: CONCERT PHARMACEUTICALS INC. [--/US]; 99 Hayden Avenue, Suite 100, Lexington, MA 02421 (US) (AE, AG, AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GW, HN, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, MG, MK, ML, MN, MR, MW, MX, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SI, SK, SL, SM, SN, SY, SZ, TD, TG, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW only).
TUNG, Roger [US/US]; (US) (For US Only)
Inventors: TUNG, Roger; (US)
Agent: HSI, Jeffrey, D.; Edwards Angell Palmer & Dodge LLP, P.O. Box 55874, Boston, MA 02205 (US)
Priority Data:
60/703,570 29.07.2005 US
60/703,612 29.07.2005 US
Title (EN) NOVEL PHARMACEUTICAL COMPOUNDS
(FR) NOUVEAUX COMPOSES PHARMACEUTIQUES
Abstract: front page image
(EN)The present invention relates to derivatives of tadalafil, substituted with fluorine on the methylene carbon atom situated between the oxygens of the benzodioxol ring, and optionally further substituted with deuterium atoms in place of normally abundant hydrogen, and 13C in place of normally abundant 12C. These compounds are selective PDE5 inhibitors and possess advantageous biopharmaceutical and pharmacokinetic properties. The invention further provides compositions comprising these compounds and methods of treating diseases and conditions that are responsive to PDE5 inhibition, alone and in combination with additional agents.
(FR)La présente invention concerne des dérivés de tadalafil, substitués par du fluor sur l'atome de méthylène carbone situé entre les oxygènes de l'anneau benzodioxol, et éventuellement encore substitués par des atomes de deutérium à la place de l'hydrogène normalement abondant, et C13 à la place du C12 normalement abondant. Ces composés sont des inhibiteurs de PDE5 sélectifs et possèdent des propriétés biopharmaceutiques et pharmacocinétiques avantageuses. La présente invention porte par ailleurs sur des compositions comprenant ces composés ainsi que sur des procédés permettant de traiter les maladies et des états qui répondent à l'inhibition de PDE5, seul et en combinaison avec des agents supplémentaires.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)