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1. (WO2007016354) MULTICYCLIC SULFONAMIDE COMPOUNDS AS INHIBITORS OF HISTONE DEACETYLASE FOR THE TREATMENT OF DISEASE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/016354    International Application No.:    PCT/US2006/029438
Publication Date: 08.02.2007 International Filing Date: 27.07.2006
IPC:
C07D 405/12 (2006.01), C07D 401/12 (2006.01), C07D 405/14 (2006.01), C07D 413/12 (2006.01), C07D 417/12 (2006.01), C07D 401/14 (2006.01), A61K 31/4427 (2006.01), A61P 9/00 (2006.01), A61P 25/00 (2006.01), A61P 29/00 (2006.01), A61P 35/00 (2006.01)
Applicants: KALYPSYS, INC. [US/US]; 10420 Wateridge Circle, San Diego, CA 92121 (US) (For All Designated States Except US).
WASH, Paul, L. [US/US]; (US) (For US Only).
MALECHA, James, W. [US/US]; (US) (For US Only).
NOBLE, Stewart, A. [GB/US]; (US) (For US Only).
HOFFMAN, Timothy, Z. [US/US]; (US) (For US Only).
BONNEFOUS, Celine [FR/US]; (US) (For US Only).
SMITH, Nicholas, D. [US/US]; (US) (For US Only).
HASSIG, Christian, A. [US/US]; (US) (For US Only).
SCRANTON, Shawn, A. [US/US]; (US) (For US Only).
PAYNE, Joseph, E. [CA/US]; (US) (For US Only).
HAGER, Jeffrey, H. [US/US]; (US) (For US Only).
SERTIC, Michael [US/US]; (US) (For US Only).
WILEY, Brandon, M. [US/US]; (US) (For US Only)
Inventors: WASH, Paul, L.; (US).
MALECHA, James, W.; (US).
NOBLE, Stewart, A.; (US).
HOFFMAN, Timothy, Z.; (US).
BONNEFOUS, Celine; (US).
SMITH, Nicholas, D.; (US).
HASSIG, Christian, A.; (US).
SCRANTON, Shawn, A.; (US).
PAYNE, Joseph, E.; (US).
HAGER, Jeffrey, H.; (US).
SERTIC, Michael; (US).
WILEY, Brandon, M.; (US)
Agent: HO, Raymond. J.; International Patent Group, Post Office Box 38129, St. Louis, MO 63138 (US)
Priority Data:
60/704,091 29.07.2005 US
60/780,129 07.03.2006 US
Title (EN) MULTICYCLIC SULFONAMIDE COMPOUNDS AS INHIBITORS OF HISTONE DEACETYLASE FOR THE TREATMENT OF DISEASE
(FR) COMPOSES DE SULFONAMIDE MULTICYCLIQUE UTILISES EN TANT QU'INHIBITEURS D'HISTONE DESACETYLASE POUR LE TRAITEMENT DE MALADIES
Abstract: front page image
(EN)Disclosed herein are sulfonamide compounds of Formula (VII) as described herein. Methods and compositions are disclosed for treating disease states including, but not limited to cancers, autoimmune diseases, tissue damage, central nervous system disorders, neurodegenerative disorders, fibrosis, bone disorders, polyglutamine-repeat disorders, anemias, thalassemias, inflammatory conditions, cardiovascular conditions, and disorders in which angiogenesis play a role in pathogenesis, using the compounds of the invention. In addition, methods of modulating the activity of histone deacetylase (HDAC) are also disclosed.
(FR)La présente invention concerne les composés de sulfonamide de Formule (VII) tels que décrits ici. L'invention concerne des procédés et des compositions permettant de traiter, au moyen desdits composés, des états pathologiques incluant, mais sans s'y limiter, les cancers, les maladies auto-immunes, les détériorations de tissus, les troubles du système nerveux central, les troubles à neurodégénérescence, la fibrose, les troubles osseux, les troubles liés à la répétition de polyglutamine, les anémies, les thalassémies, les maladies inflammatoires, les maladies cardiovasculaires et les troubles dans lesquels l'angiogénèse joue un rôle dans la pathogénèse. Par ailleurs, l'invention concerne également des procédés de modulation de l'activité de l'histone déacétylase (HDAC).
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)