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1. (WO2007016254) ANTINEOPLASTIC ACTIVITIES OF ELLIPTICINE AND ITS DERIVATIVES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/016254    International Application No.:    PCT/US2006/029212
Publication Date: 08.02.2007 International Filing Date: 27.07.2006
IPC:
A61K 31/437 (2006.01), A61P 35/00 (2006.01)
Applicants: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS [US/US]; 2404 North University Avenue, Little Rock, AR 72207-3608 (US) (For All Designated States Except US)
Inventors: SHAUGHNESSY, John; (US).
TIAN, Erming; (US)
Agent: ADLER, Benjamin, A.; Adler & Associates, 8011 Candle Lane, Houston, TX 77071 (US)
Priority Data:
60/702,944 27.07.2005 US
Title (EN) ANTINEOPLASTIC ACTIVITIES OF ELLIPTICINE AND ITS DERIVATIVES
(FR) ACTIVITES ANTINEOPLASIQUES DE L'ELLIPTICINE ET DE SES DERIVES
Abstract: front page image
(EN)The present invention describes selective cell growth inhibition of myeloma cells by ellipticine derivatives, 9-methoxy ellipticine and 9-dimethyl amino-ethoxy ellipticine. The cell growth inhibition efficacy was highest for 9-dimethyl amino-ethoxy ellipticine among the ellipcitine derivatives tested. The cell toxicity of 9-dimethyl amino-ethoxy ellipticine was selective for myeloma cells and did not kill normal cells in the effective antineoplastic dose range. 9-dimethyl amino-ethoxy ellipticine was superior to existing antimyeloma drugs, Adriamycin® and Etoposide in eliciting early and better cell growth inhibition response.
(FR)La présente invention porte sur l'inhibition sélective de la croissance cellulaire de cellules myélomateuses par des dérivés de l'ellipticine, la 9-méthoxy ellipticine et la 9-diméthyl amino-éthoxy ellipticine. Parmi les dérivés de l'ellipticine testés, la 9-diméthyl amino-éthoxy ellipticine s'est révélée être la plus efficace pour inhiber la croissance cellulaire. La toxicité cellulaire de la 9-diméthyl amino-éthoxy ellipticine s'est montrée sélective pour les cellules myélomateuses et n'a pas tué de cellules normales dans la marge posologique antinéoplasique effective. La 9-diméthyl amino-éthoxy ellipticine s'est avérée plus efficace que des médicaments antimyélomes existants, tels que l'Adriamycine$m(3) et l'Etoposide, pour provoquer une réponse rapide et meilleure d'inhibition de la croissance cellulaire.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)