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1. (WO2007016221) HYALURONAN SYNTHASES AND METHODS OF MAKING AND USING SAME
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/016221    International Application No.:    PCT/US2006/029145
Publication Date: 08.02.2007 International Filing Date: 28.07.2006
IPC:
C12P 19/28 (2006.01), C08B 37/00 (2006.01), C12N 1/21 (2006.01)
Applicants: THE BOARD OF REGENTS OF UNIVERSITY OF OKLAHOMA [US/US]; 660 Parrington Oval, Room 119 Norman, OK 73019 (US) (For All Designated States Except US).
DEANGELIS, Paul, L. [US/US]; (US) (For US Only).
WEIGEL, Paul, H. [US/US]; (US) (For US Only).
PUMMILL, Phillip; (US) (For US Only)
Inventors: DEANGELIS, Paul, L.; (US).
WEIGEL, Paul, H.; (US).
PUMMILL, Phillip; (US)
Agent: HESTER, Kathryn, L.; DUNLAP, CODDING & ROGERS, P.C., P.O. Box 16370, Oklahoma City, OK 73113 (US)
Priority Data:
60/704,003 29.07.2005 US
Title (EN) HYALURONAN SYNTHASES AND METHODS OF MAKING AND USING SAME
(FR) HYALURONAN SYNTHASES ET LEURS PROCEDES DE FABRICATION ET D'UTILISATION
Abstract: front page image
(EN)A functionally active hyaluronan synthase having at least one modified amino acid residue therein as compared to a corresponding functionally active native hyaluronan synthase such that the functionally active hyaluronan synthase has an altered enzymatic activity as compared to the corresponding functionally active native hyaluronan synthase is disclosed. The altered enzymatic activity may result in increased or decreased activity when compared to the corresponding native hyaluronan synthase, or the altered enzymatic activity may result in production of hyaluronan having an average molecular mass that is greater than or less than an average molecular mass of hyaluronan produced by the corresponding native hyaluronan synthase. Methods of producing hyaluronic acid utilizing a recombinant host cell having an expression construct encoding the functionally active hyaluronan synthase with altered enzymatic activity are also disclosed.
(FR)L'invention concerne une hyaluronan synthase fonctionnellement active renfermant au moins un résidu d'acide aminé modifié par rapport à une hyaluronan synthase native fonctionnellement active correspondante, de sorte que la hyaluronan synthase fonctionnellement active présente une activité enzymatique altérée par rapport à la hyaluronan synthase native fonctionnellement active correspondante. L'activité enzymatique altérée peut résulter en une activité accrue ou réduite en comparaison de la hyaluronan synthase native correspondante, ou dans la production d'une hyaluronan dont la masse moléculaire moyenne est supérieure ou inférieure à celle d'une hyaluronan produite par la hyaluronan synthase native correspondante. L'invention concerne également des procédés de production d'acide hyaluronique faisant appel à une cellule hôte de recombinaison présentant une construction d'expression codant la hyaluronan synthase native fonctionnellement active avec l'activité enzymatique altérée.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)