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1. (WO2007016164) CAT1 TRANSPORTERS EXPRESSED IN BLOOD BRAIN BARRIER CELLS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/016164    International Application No.:    PCT/US2006/029042
Publication Date: 08.02.2007 International Filing Date: 25.07.2006
IPC:
G01N 33/50 (2006.01), G01N 33/68 (2006.01), G01N 33/94 (2006.01), A61K 47/48 (2006.01)
Applicants: XENOPORT, INC. [US/US]; 3410 Central Expressway, Santa Clara, California 95051-0703 (US) (For All Designated States Except US).
ZERANGUE, Noa [US/US]; (US) (For US Only)
Inventors: ZERANGUE, Noa; (US)
Agent: HAYNES, Jennifer; Two Embarcadero Center, 8th Floor, San Francisco, California 94111-3834 (US)
Priority Data:
60/703,571 29.07.2005 US
Title (EN) CAT1 TRANSPORTERS EXPRESSED IN BLOOD BRAIN BARRIER CELLS
(FR) TRANSPORTEURS CAT1 EXPRIMES DANS LES CELLULES DE LA BARRIERE HEMATO-ENCEPHALIQUE
Abstract: front page image
(EN)CAT1 is consistently expressed at high levels in brain microvessel endothelial cells. Disclosed herein are assays for determining whether a test material/molecule is a substrate for, and/or is actively transported by, the CAT1 transporter, and therefore a candidate substrate for crossing the blood brain barrier. The assays are useful in screening for therapeutic, cytotoxic or imaging compounds used in the treatment or diagnosis of neurological diseases.
(FR)CAT1 est exprimé uniformément à des niveaux élevés dans les cellules endothéliales des microvaisseaux cérébraux. Cette invention concerne des analyses servant à déterminer si un matériau ou une molécule d'essai constitue un substrat pour le transporteur CAT1, et/ou est activement transporté(e) par le transporteur CAT1, et constitue de ce fait un substrat potentiel pour traverser la barrière hémato-encéphalique. Ces analyses servent à cribler des composés thérapeutiques, des composés cytotoxiques ou des composés d'imagerie utilisés pour traiter ou diagnostiquer des maladies neurologiques.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)