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Machine translation
1. (WO2007016150) MUTATED PSEUDOMONAS EXOTOXINS WITH REDUCED ANTIGENICITY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/016150    International Application No.:    PCT/US2006/028986
Publication Date: 08.02.2007 International Filing Date: 25.07.2006
IPC:
C07K 14/195 (2006.01), C07K 14/21 (2006.01), C07K 19/00 (2006.01), A61K 38/16 (2006.01), A61K 47/48 (2006.01)
Applicants: THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY OF HEALTH AND HUMAN SERVICES NATIONAL INSTITUTES OF HEALTH [US/US]; 6011 Executive Boulevard, Suite 325, Rockville, Maryland 20852 (US) (For All Designated States Except US).
PASTAN, Ira, H. [US/US]; (US) (For US Only).
ONDA, Masanori [JP/US]; (US) (For US Only).
NAGATA, Satoshi [JP/US]; (US) (For US Only).
FITZGERALD, David [US/US]; (US) (For US Only).
KREITMAN, Robert [US/US]; (US) (For US Only).
LEE, Byungkook [US/US]; (US) (For US Only)
Inventors: PASTAN, Ira, H.; (US).
ONDA, Masanori; (US).
NAGATA, Satoshi; (US).
FITZGERALD, David; (US).
KREITMAN, Robert; (US).
LEE, Byungkook; (US)
Agent: HYMAN, Laurence, J.; Townsend and Townsend and Crew LLP, 2 Embarcadero Center, 8th Floor, San Francisco, California 94111 (US)
Priority Data:
60/703,798 29.07.2005 US
Title (EN) MUTATED PSEUDOMONAS EXOTOXINS WITH REDUCED ANTIGENICITY
(FR) EXOTOXINES DE PSEUDOMONAS MUTEES A ANTIGENICITE REDUITE
Abstract: front page image
(EN)The invention provides mutated Pseudomonas exotoxins (PE) that have reduced immunogenicity compared to PEs containing the native sequence. The PEs of the invention have one or more individual mutations of positions of the native sequence of PE that reduce antibody binding to one or more PE epitopes. Nucleic acids encoding the mutated PEs, chimeric molecules comprising them, compositions comprising the chimeric molecules and methods of using them, are also provided.
(FR)L'invention concerne des exotoxines de Pseudomonas (PE) qu'ils présentent une immunologie initie des réduite par rapport aux PE contenant la séquence native. Les PE de l'invention possèdent une ou plusieurs mutations individuelles de positions de la séquence native de PE qui réduit la liaison d'anticorps à un ou plusieurs épitopes PE. L'invention concerne également des acides nucléiques codant les PE mutés, des molécules chimères les contenant, des compositions contenant ces molécules chimères et des procédés d'utilisation de ceux-ci.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)