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1. (WO2007016144) OCTN2 TRANSPORTERS EXPRESSED IN BLOOD BRAIN BARRIER CELLS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/016144    International Application No.:    PCT/US2006/028973
Publication Date: 08.02.2007 International Filing Date: 25.07.2006
IPC:
G01N 33/50 (2006.01), G01N 33/68 (2006.01), G01N 33/94 (2006.01)
Applicants: XENOPORT, INC. [US/US]; 3410 Central Expressway, Santa Clara, CA 95051 (US) (For All Designated States Except US).
ZERANGUE, Noa [US/US]; (US) (For US Only)
Inventors: ZERANGUE, Noa; (US)
Agent: HAYNES, Jennifer; TOWNSEND AND TOWNSEND AND CREW LLP, TWO EMBARCADERO CENTER, 8th Floor, San Francisco, CA 94111-3834 (US)
Priority Data:
60/703,572 29.07.2005 US
Title (EN) OCTN2 TRANSPORTERS EXPRESSED IN BLOOD BRAIN BARRIER CELLS
(FR) TRANSPORTEURS OCTN2 EXPRIMES DANS DES CELLULES DE LA BARRIERE HEMATO-ENCEPHALIQUE
Abstract: front page image
(EN)OCTN2 is consistently expressed at high levels in brain microvessel endothelial cells. Disclosed herein are assays for determining whether a test material/molecule is a substrate for, and/or is actively transported by, the OCTN2 transporter, and therefore a candidate substrate for crossing the blood brain barrier. The assays are useful in screening for therapeutic, cytotoxic or imaging compounds used in the treatment or diagnosis of neurological diseases.
(FR)L'invention concerne l'expression uniforme OCTN2 à des niveaux élevés dans les cellules endothéliales des micro-vaisseaux du cerveau. L'invention concerne également des essais biologiques permettant de déterminer si un matériau/une molécule d'essai est un substrat pour le, et/ou est activement transporté par, le transporteur OCTN2, et donc est un substrat candidat pour traverser la barrière hémato-encéphalique. Les essais biologiques sont utiles dans le criblage de composés thérapeutiques, cytotoxiques ou d'imagerie utilisés dans le traitement ou le diagnostic de maladies neurologiques.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)