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1. (WO2007016099) PROTECTION OF TRANSPLANTED STEM CELLS WITH HMG-COA REDUCTASE INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/016099    International Application No.:    PCT/US2006/028860
Publication Date: 08.02.2007 International Filing Date: 26.07.2006
IPC:
A61K 31/41 (2006.01)
Applicants: MUSC FOUNDATION FOR RESEARCH DEVELOPMENT [US/US]; P.O. Box 250194, Charleston, SC 29425 (US) (For All Designated States Except US).
SINGH, Inderjit [US/US]; (US) (For US Only).
SINGH, Avtar, K. [US/US]; (US) (For US Only)
Inventors: SINGH, Inderjit; (US).
SINGH, Avtar, K.; (US)
Agent: KRAWZSENEK, Michael, R.; FULBRIGHT & JAWORSKI L.L.P., 600 Congress Avenue, Suite 2400, Austin, Texas 78701 (US)
Priority Data:
60/704,129 29.07.2005 US
Title (EN) PROTECTION OF TRANSPLANTED STEM CELLS WITH HMG-COA REDUCTASE INHIBITORS
(FR) PROTECTION DE CELLULES SOUCHES TRANSPLANTÉES AVEC DES INHIBITEURS DE HMG-COA RÉDUCTASE
Abstract: front page image
(EN)Impaired remyeliiiation due to degeneration of both postmitotic oligodendrocytes and oligodendrocyte progenitors (OPs) is the major hallmark of inflammatory demyelination in multiple sclerosis (MS) lesions and other inflammatory diseases. HMG-CoA reductase inhibitors also are proposed to stimulate and protect stems cells, such as OPs, for example in the context of transplantation.
(FR)La remyélinisation diminuée due à la dégénération des oligodendrocytes postmitotiques ainsi que des progéniteurs d’oligodendrocyte (OPs) est la marque principale de la demyélinisation inflammatoire dans les lésions de la sclérose en plaques (MS) et d’autres maladies inflammatoires. Des inhibiteurs de HMG-CoA réductase sont également proposés pour stimuler et protéger des cellules souches, telles que des OPs, par exemple dans le contexte d’une transplantation.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)