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1. (WO2007015807) PHENYL COMPOUNDS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/015807    International Application No.:    PCT/US2006/027673
Publication Date: 08.02.2007 International Filing Date: 14.07.2006
C07C 237/30 (2006.01), C07C 237/44 (2006.01), A61K 31/166 (2006.01), A61P 3/10 (2006.01)
Applicants: ELI LILLY AND COMPANY [US/US]; Lilly Corporate Center, Indianapolis, IN 46285 (US) (For All Designated States Except US).
BLASZCZAK, Larry, Chris [US/US]; (US) (For US Only).
PULLEY, Shon, Roland [US/US]; (US) (For US Only).
ROBERTSON, Michael, Alan [US/US]; (US) (For US Only).
SHEEHAN, Scott, Martin [US/US]; (US) (For US Only).
SHI, Qing [US/US]; (US) (For US Only).
WATSON, Brian, Morgan [US/US]; (US) (For US Only).
WILEY, Michael, Robert [US/US]; (US) (For US Only)
Inventors: BLASZCZAK, Larry, Chris; (US).
PULLEY, Shon, Roland; (US).
ROBERTSON, Michael, Alan; (US).
SHEEHAN, Scott, Martin; (US).
SHI, Qing; (US).
WATSON, Brian, Morgan; (US).
WILEY, Michael, Robert; (US)
Agent: VORNDRAN-JONES, MaCharri; Eli Lilly and Company, P.O. Box 6288, Indianapolis, IN 46206-6288 (US)
Priority Data:
60/700,784 20.07.2005 US
Abstract: front page image
(EN)The present invention is directed to compounds of formula (I) or a pharmaceutically acceptable salt thereof; wherein A is (xx) ; X is selected from CH, CF and N, R5 is selected from H, C1-C6 alkyl, C1-C6 fluoroalkyl, and -OR12, R9 is selected from H and -C(O)NRlORl 1, R12 is selected from H, C1-C6 alkyl and C3-C6 cycloalkyl for use as inhibitors of the DPP-IV enzyme in the treatment or prevention of conditions including Type II diabetes.
(FR)La présente invention concerne des composés de formule (I) ou un sel pharmaceutiquement acceptable de ces composés ; A étant représenté par la formule (II) ; X étant choisi parmi CH, CF et N, R5 étant choisi parmi H, un alkyle en C1-C6, un fluoroalkyle en C1-C6, et -OR12, R9 étant choisi parmi H et -C(O)NRlORl 1, R12 étant choisi parmi H, un alkyle en C1-C6, et un cycloalkyle en C3-C6 ; destinés à une utilisation en tant qu'inhibiteurs de l'enzyme DPP-IV dans le traitement ou la prévention de troubles incluant le diabète de type II.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)