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1. (WO2007015265) A PROCESS FOR PREPARING 6,9-IMINO ETHER
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/015265    International Application No.:    PCT/IN2006/000180
Publication Date: 08.02.2007 International Filing Date: 24.05.2006
IPC:
C07H 17/08 (2006.01)
Applicants: KOPRAN RESEARCH LABORATORIES LTD [IN/IN]; Parijat House, 1076 Dr E Moses Road, Worli, Mumbai 400 018, Maharashtra (IN) (For All Designated States Except US).
MADHAORAO, Mahajan, Kiran [IN/IN]; (IN) (For US Only).
LAXMAN, Patil, Gokul [IN/IN]; (IN) (For US Only).
BALWANT, Chawan, Mangesh [IN/IN]; (IN) (For US Only).
MADHAV, Hire, Chandrabhan [IN/IN]; (IN) (For US Only).
VISWANATH, Ambre, Rajesh [IN/IN]; (IN) (For US Only).
YASHWANT, Randive, Sachin [IN/IN]; (IN) (For US Only)
Inventors: MADHAORAO, Mahajan, Kiran; (IN).
LAXMAN, Patil, Gokul; (IN).
BALWANT, Chawan, Mangesh; (IN).
MADHAV, Hire, Chandrabhan; (IN).
VISWANATH, Ambre, Rajesh; (IN).
YASHWANT, Randive, Sachin; (IN)
Agent: MADAN, Jose, A.; Khaitan & Co, Meher Chambers, 4th & 5th Floors, R K Marg, Ballard Estate, Mumbai 400 038 Maharashtra (IN)
Priority Data:
627/MUM/2005 24.05.2005 IN
Title (EN) A PROCESS FOR PREPARING 6,9-IMINO ETHER
(FR) FABRICATION DE 6,9-IMINO ETHER
Abstract: front page image
(EN)A process for preparing 6,9-lmino ether from Erythromycin thiocyanate without isolating Erythromycin base and Erythromycin oxime and Beckmann's rearrangement of erythromycin oxime is carried in the presence biphasic solvent system comprising methylene chloride and water in the presence of triethylamine along with sodium bicarbonate to obtain 87-96 % pure 6,9-lmino ether. Further the 6,9-lmino ether is hydrogenated to 9-Deoxo-9a-aza-9a-homoerythromycin A followed by reductive methylation to obtain Azithromycin dihydrate.
(FR)Procédé de fabrication de 6,9-imino éther à partir de thiocyanate d'érythromycine sans isolement d'une base d'érythromycine et d'un oxime d'érythromicine, dans lequel un réagencement Beckmann d'oxime d'érythromycine a lieu avec un système de solvant biphasique comprenant du chlorure de méthylène et de l'eau en présence de triéthylamine et de bicarbonate de soude, le but étant d'obtenir un 6,9-Imino éther pur à 87-96 %. Le 6,9-imino éther est ensuite hydrogéné en 9-déoxo-9a-aza-9a-homoérythromycine, puis soumis à une méthylation réductive pour obtenir un dihydrate d'azithromicine.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)