WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2007015262) A PROCESS FOR THE PREPARATION OF (-)-TRANS-4-(P-FLUOROPHENYL)-3-[[3,4-(METHYLENEDIOXY)PHENOXY]METHYL)]PIPERIDINE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/015262    International Application No.:    PCT/IN2006/000138
Publication Date: 08.02.2007 International Filing Date: 24.04.2006
IPC:
C07D 405/00 (2006.01), C07D 405/02 (2006.01), C07D 405/12 (2006.01), C07D 407/12 (2006.01), A61K 31/4525 (2006.01), A61P 25/00 (2006.01), A61P 25/24 (2006.01)
Applicants: SUN PHARMACEUTICAL INDUSTRIES LIMITED [IN/IN]; ACME Plaza, Andheri-kurla Road, Andheri (East), Mumbai 400 059 (IN) (For All Designated States Except US).
MISTRY, Ankur Bhupendrakumar [IN/IN]; (IN) (For US Only).
PILLAI, Mandakini Mutthukumaran [IN/IN]; (IN) (For US Only).
PATEL, Vijaykumar Muljibhai [IN/IN]; (IN) (For US Only).
CHITTURI, Trinadha Rao [IN/IN]; (IN) (For US Only).
THENNATI, Rajamannar [IN/IN]; (IN) (For US Only)
Inventors: MISTRY, Ankur Bhupendrakumar; (IN).
PILLAI, Mandakini Mutthukumaran; (IN).
PATEL, Vijaykumar Muljibhai; (IN).
CHITTURI, Trinadha Rao; (IN).
THENNATI, Rajamannar; (IN)
Priority Data:
506/MUM/2005 25.04.2005 IN
Title (EN) A PROCESS FOR THE PREPARATION OF (-)-TRANS-4-(P-FLUOROPHENYL)-3-[[3,4-(METHYLENEDIOXY)PHENOXY]METHYL)]PIPERIDINE
(FR) PROCEDE POUR PREPARER DE LA (-)-TRANS-4-(4-FLUOROPHENYL)-3-[[3,4-(METHYLENEDIOXY)PHENOXY]METHYL]PIPERIDINE
Abstract: front page image
(EN)A process for preparing (-)-trans-4-(4-fluorophenyl)-3-[[3,4-(methylenedioxy)phenoxy]methyl]-piperidine, a compound of formula (I) or pharmaceutically acceptable salts thereof, said process comprising hydrolyzing a compound of formula (II), wherein R may be selected from halo substituted or unsubstituted linear, branched or cyclic alkyl, alkylaryl, arylalkyl, by treatment with a base in a solvent system comprising a polar aprotic water miscible solvent and a hydrocarbon solvent wherein the polar aprotic water miscible solvent is selected from a sulfoxide solvent, an amide solvent or mixture thereof.
(FR)La présente invention concerne un procédé pour préparer de la (-)-trans-4-(4-fluorophényl)-3-[[3,4-(méthylènedioxy)phénoxy]méthyl]-pipéridine, un composé de formule (I) ou des sels de celui-ci, acceptables d'un point de vue pharmaceutique. Ledit procédé consiste à hydrolyser un composé de formule (II), dans laquelle R peut être choisi parmi alkyle, aryle, alkylaryle, arylalkyle linéaire, ramifié ou cyclique, à substitution halo ou non substitué, au moyen d'un traitement avec une base dans un système de solvants comprenant un solvant aprotique polaire miscible à l'eau et un solvant à base d'hydrocarbure. Ledit solvant aprotique polaire miscible à l'eau est choisi parmi un solvant à base de sulfoxyde, un solvant à base d'amide, du sulfolane ou un mélange de ceux-ci.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)