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1. (WO2007015259) METHOD OF SYNTHESIZING KEY INTERMEDIATES FOR THE PRODUCTION OF CAMPTOTHECIN DERIVATIVES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/015259    International Application No.:    PCT/IN2005/000326
Publication Date: 08.02.2007 International Filing Date: 27.09.2005
IPC:
C07C 209/36 (2006.01), C07C 201/08 (2006.01), C07C 205/45 (2006.01)
Applicants: AVRA LABORATORIES PVT. LTD. [IN/IN]; AVRA House, 54 Sai Enclave, Habsiguda, Hyderabad 500 007, Andhara Pradesh (IN) (For All Designated States Except US).
RAO, Ramakrishna [IN/IN]; (IN) (For US Only).
ALLA, Venkata, Rama, Rao [IN/IN]; (IN) (For US Only)
Inventors: ALLA, Venkata, Rama, Rao; (IN)
Agent: NAIR, Gopakumar, G.; Gopakumar Nair Associates, Nair Baug, Akurli Road, Kandivli (East), Mumbai 400 101, Maharashtra (IN)
Priority Data:
1053/CHE/2005 03.08.2005 IN
Title (EN) METHOD OF SYNTHESIZING KEY INTERMEDIATES FOR THE PRODUCTION OF CAMPTOTHECIN DERIVATIVES
(FR) PROCEDE DE SYNTHESE D'INTERMEDIAIRES CLES POUR LA PRODUCTION DE DERIVES DE CAMPTOTHECINE
Abstract: front page image
(EN)The present invention discloses a process for efficient production of 2-amino-5- hydroxypropiophenone corresponding to the AB ring part of camptothecin (CPT) skelton, which is a key intermediate useful for the total synthesis of camptothecin analogs including 7-Ethyl-10-hydroxy camptothecin and novel intermediates thereof.
(FR)La présente invention concerne un procédé de production efficace de 2-amino-5-hydroxypropiophénone correspondant à la partie cyclique AB du squelette de la camptothécine (CPT) qui est un intermédiaire clé utile pour la synthèse totale d'analogues de la camptothécine, notamment de la 7-éthyl-10-hydroxycamptothécine, et de nouveaux intermédiaires associés.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)