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1. (WO2007014927) MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/014927    International Application No.:    PCT/EP2006/064822
Publication Date: 08.02.2007 International Filing Date: 28.07.2006
IPC:
C07D 417/04 (2006.01), C07D 239/72 (2006.01), A61K 31/517 (2006.01), A61P 31/12 (2006.01)
Applicants: TIBOTEC PHARMACEUTICALS LTD. [IE/IE]; Eastgate Village, Eastgate, Little Island, Co Cork (IE) (For All Designated States Except US).
MEDIVIR AB [SE/SE]; Lunastigen 7, S-141 44 Huddinge (SE) (For All Designated States Except US).
RABOISSON, Pierre, Jean-Marie, Bernard [FR/BE]; (BE) (For US Only).
DE KOCK, Herman, Augustinus [BE/BE]; (BE) (For US Only).
HU, Lili [NL/BE]; (BE) (For US Only).
SIMMEN, Kenneth, Alan [GB/BE]; (BE) (For US Only).
LINDQUIST, Karin, Charlotta [SE/SE]; (SE) (For US Only).
LINDSTRÖM, Mats, Stefan [SE/SE]; (SE) (For US Only).
BELFRAGE, Anna, Karin, Gertrud, Linnea [SE/SE]; (SE) (For US Only).
WÄHLING, Horst, Jürgen [DE/SE]; (SE) (For US Only).
NILSSON, Karl, Magnus [SE/SE]; (SE) (For US Only).
SAMUELSSON, Bengt, Bertil [SE/SE]; (SE) (For US Only).
ROSENQUIST, Åsa, Annica, Kristina [SE/SE]; (SE) (For US Only).
SAHLBERG, Sven, Crister [SE/SE]; (SE) (For US Only).
WALLBERG, Hans, Kristian [SE/SE]; (SE) (For US Only).
KAHNBERG, Pia, Cecilia [SE/SE]; (SE) (For US Only).
CLASSON, Björn, Olof [SE/SE]; (SE) (For US Only)
Inventors: RABOISSON, Pierre, Jean-Marie, Bernard; (BE).
DE KOCK, Herman, Augustinus; (BE).
HU, Lili; (BE).
SIMMEN, Kenneth, Alan; (BE).
LINDQUIST, Karin, Charlotta; (SE).
LINDSTRÖM, Mats, Stefan; (SE).
BELFRAGE, Anna, Karin, Gertrud, Linnea; (SE).
WÄHLING, Horst, Jürgen; (SE).
NILSSON, Karl, Magnus; (SE).
SAMUELSSON, Bengt, Bertil; (SE).
ROSENQUIST, Åsa, Annica, Kristina; (SE).
SAHLBERG, Sven, Crister; (SE).
WALLBERG, Hans, Kristian; (SE).
KAHNBERG, Pia, Cecilia; (SE).
CLASSON, Björn, Olof; (SE)
Agent: DAELEMANS, Frank; Tibotec-Virco Comm. VA, J & J Patent Law Department, Generaal De Wittelaan L 11b 3, B-2800 Mechelen (BE)
Priority Data:
05107057.1 29.07.2005 EP
06113097.7 25.04.2006 EP
Title (EN) MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS
(FR) INHIBITEURS MACROCYCLIQUES DU VIRUS DE L'HEPATITE C
Abstract: front page image
(EN)Compounds of the formula (I), and N-oxides, salts, and stereoisomers thereof wherein A is OR1, NHS(=O)PR2; wherein; R1 is hydrogen, C1-C6alkyl, C0-C3alkylenecarbocyclyl, C0-C3alkylene-heterocyclyl; R2 is C1-C6alkyl, C0-C3alkylenecarbocyclyl, C0-C3alkyleneheterocyclyl; p is independently 1 or 2; n is 3, 4, 5 or 6; ---- deonotes an optional double bond; L is N or CRz; Rz is H or forms a double bond with the asterisked carbon; Rq is H or when L is CRz, Rq can also be C1-C6alkyl; Rr is quinazolinyl, optionally substituted with one two or three substituents each independently selected from C1-C6 alkyl, C1-C6alkoxy, hydroxyl, halo, haloC1-C6alkyl, amino, mono- or dialkylamino, mono- or dialkylaminocarbonyl, C1-C6alkyl- carbonylamino, C0-C3alkylenecarbocyclyl and C0-C3 alkyleneheterocyclyl; R5 is hydrogen, C1-C6alkyl, C1-C6alkoxyC1-C6alkyl or C3-C7cycloalkyl; R6 is hydrogen, C1-C6alkyl, C1-C6alkoxy, C0-C3alkylenecarbocyclyl, C0-C3alkyleneheterocyclyl, hydroxy, bromo, chloro or fluoro have utility in the treatment or prophylaxis of flaviviral infections such as HCV.
(FR)L'invention concerne des composés de formule (I) et des N-oxydes, sels, et stéréoisomères de ceux-ci. Dans ladite formule : A représente OR1, NHS(=O)PR2 ; R1 représentant hydrogène, C1-C6 alkyle, C0-C3 alkylènecarbocyclyle, C0-C3 alkylènehétérocyclyle ; R2 représentant C1-C6 alkyle, C0-C3 alkylènecarbocyclyle, C0-C3 alkylènehétérocyclyle ; p valant indépendamment 1 ou 2 ; n valant 3, 4, 5 ou 6; ---- représentant une double liaison facultative; L représente N ou CRz ; Rz représentant H ou formant une double liaison avec le carbone marqué par un astérisque ; Rq représente H ou, lorsque L représente CRz, Rq peut également représenter C1-C6 alkyle ; Rr représente quinazolinyle, éventuellement substitué par deux ou trois substituants chacun indépendamment sélectionné parmi C1-C6 alkyle, C1-C6 alcoxy, hydroxyle, halo, halo C1-C6 alkyle, amino, mono- ou dialkylamino, mono- ou dialkylaminocarbonyle, C1-C6 alkyl-carbonylamino, C0-C3 alkylènecarbocyclyle et C0-C3 alkylènehétérocyclyle ; R5 représente hydrogène, C1-C6alkyle, C1-C6 alcoxy, C1-C6 alkyle ou C3-C7 cycloalkyle ; R6 représente hydrogène, C1-C6 alkyle, C1-C6 alcoxy, C0-C3 alkylènecarbocyclyle, C0-C3 alkylènehétérocyclyle, hydroxy, bromo, chloro ou fluoro. Lesdits composés sont utiles dans le traitement ou la prophylaxie d'infections flavivirales de type virus de l'hépatite C.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)