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1. (WO2007014784) ANTITUMORAL BIOCONJUGATES OF HYALURONIC ACID OR ITS DERIVATIVES OBTAINED BY INDIRECT CHEMICAL CONJUGATION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/014784    International Application No.:    PCT/EP2006/007717
Publication Date: 08.02.2007 International Filing Date: 02.08.2006
IPC:
A61K 47/48 (2006.01)
Applicants: FIDIA FARMACEUTICI S.P.A. [IT/IT]; Via Ponte della Fabbrica, 3/A, I-35031 Abano Terme-Padova (IT) (For All Designated States Except US).
RENIER, Davide [IT/IT]; (IT) (For US Only).
BETTELLA, Fabio [IT/IT]; (IT) (For US Only)
Inventors: RENIER, Davide; (IT).
BETTELLA, Fabio; (IT)
Agent: DE GREGORI, Antonella; Barzano' & Zanardo Milano S.p.A, Via Borgonuovo 10, I-20121 Milan (IT)
Priority Data:
PD2005A000242 03.08.2005 IT
Title (EN) ANTITUMORAL BIOCONJUGATES OF HYALURONIC ACID OR ITS DERIVATIVES OBTAINED BY INDIRECT CHEMICAL CONJUGATION
(FR) BIOCONJUGUES ANTITUMORAUX D'ACIDE HYALURONIQUE OU DE SES DERIVES OBTENUS PAR CONJUGATION CHIMIQUE INDIRECTE ET LEUR UTILISATION DANS LE DOMAINE PHARMACEUTIQUE
Abstract: front page image
(EN)The present invention describes a new group of bioconjugates which can be obtained by means of indirect synthesis, via a molecular spacer, between hyaluronic acid and/or its derivatives and drugs with an antitumoral activity belonging to different groups, their preparation process and use in the oncological field. The new derivatives, in relation to the type of bond and Substitution degree, have different physico-chemical properties which improve their tolerability and efficiency and allow a more accurate modulation of the dosage, exploiting an active targeting mechanism.
(FR)L'invention concerne un nouveau groupe de bioconjugués pouvant être obtenus par synthèse indirecte, via un espaceur moléculaire, entre un acide hyaluronique et/ou ses dérivés et des médicaments à activité antitumorale appartenant à différents groupes; leur procédé de préparation; et leur utilisation dans le domaine oncologique. Ces nouveaux dérivés, en fonction du type de liaison et du degré de substitution, possèdent différentes propriétés physico-chimiques qui permettent d'améliorer leur tolérabilité et leur efficacité et favorisent une modulation du dosage plus précise exploitant un mécanisme de ciblage actif.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)