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Machine translation
1. (WO2007014744) C-TERMINAL TNF-FAMILY LIGAND (CTL) -PRODRUG
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/014744    International Application No.:    PCT/EP2006/007581
Publication Date: 08.02.2007 International Filing Date: 31.07.2006
IPC:
C07K 14/705 (2006.01), A61K 47/48 (2006.01), C12N 15/62 (2006.01)
Applicants: UNIVERSITÄT STUTTGART [DE/DE]; Keplerstrasse 7, 70174 Stuttgart (DE) (For All Designated States Except US).
JULIUS MAXIMILIANS-UNIVERSITÄT WÜRZBURG [DE/DE]; Sanderring 2, 97070 Würzburg (DE) (For All Designated States Except US).
PFIZENMAIER, Klaus [DE/DE]; (DE) (For US Only).
WAJANT, Harald [DE/DE]; (DE) (For US Only).
WATERMANN, Iris [DE/DE]; (DE) (For US Only).
GERSPACH, Jeannette [DE/DE]; (DE) (For US Only).
MÜLLER, Dafne [DE/DE]; (DE) (For US Only)
Inventors: PFIZENMAIER, Klaus; (DE).
WAJANT, Harald; (DE).
WATERMANN, Iris; (DE).
GERSPACH, Jeannette; (DE).
MÜLLER, Dafne; (DE)
Agent: PERREY, Ralf; Müller-Boré & Partner, Grafinger Strasse 2, 81671 München (DE)
Priority Data:
10 2005 036 542.6 03.08.2005 DE
Title (EN) C-TERMINAL TNF-FAMILY LIGAND (CTL) -PRODRUG
(FR) PROMEDICAMENT CTL
Abstract: front page image
(EN)The present invention relates to a polypeptide with preferably antitumoral and/or immune modulating cytokine properties which can be activated via in vivo processing comprising a C-terminal region having specific biological activity, wherein at the N-terminus of said C-terminal region an inhibitory region, a region having a processing site, and a region which is capable of selectively recognising a macromolecule on a cell surface or a component of the extracellular matrix is arranged.
(FR)La présente invention concerne un polypeptide présentant de préférence des propriétés de cytokines antitumorales et/ou immunomodulatrices et pouvant être activé par maturation in vivo, ce polypeptide comprenant une région C-terminale possédant une activité biologique spécifique. Au niveau de la terminaison N de cette région C-terminale se trouvent une région inhibitrice, une région pourvue d'un site de maturation et une région capable de reconnaître sélectivement une macromolécule sur une surface cellulaire ou un constituant de la matrice extracellulaire.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)