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1. (WO2007014264) METHODS AND COMPOSITIONS FOR THE TREATMENT OF NEUROPATHIES AND RELATED DISORDERS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/014264    International Application No.:    PCT/US2006/029014
Publication Date: 01.02.2007 International Filing Date: 25.07.2006
IPC:
A01N 43/38 (2006.01)
Applicants: DOV PHARMACEUTICAL, INC. [US/US]; 150 Pierce Street, Somerset, NJ 08873 (US) (For All Designated States Except US).
LIPPA, Arnold, S. [US/US]; (US) (For US Only).
SKOLNICK, Phil [US/US]; (US) (For US Only).
BASILE, Anthony [US/US]; (US) (For US Only).
CHEN, Zhengming [US/US]; (US) (For US Only).
EPSTEIN, Joseph, W. [US/US]; (US) (For US Only)
Inventors: LIPPA, Arnold, S.; (US).
SKOLNICK, Phil; (US).
BASILE, Anthony; (US).
CHEN, Zhengming; (US).
EPSTEIN, Joseph, W.; (US)
Agent: KING, Jeffrey, J.; Black Lowe & Graham Pllc, 701 Fifth Avenue - Suite 4800, Seattle, WA 98104 (US)
Priority Data:
60/702,800 26.07.2005 US
11/492,608 24.07.2006 US
Title (EN) METHODS AND COMPOSITIONS FOR THE TREATMENT OF NEUROPATHIES AND RELATED DISORDERS
(FR) PROCEDES ET COMPOSITIONS POUR LE TRAITEMENT DE NEUROPATHIES ET DE TROUBLES CONNEXES
Abstract: front page image
(EN)The present invention provides novel compositions and methods for treating symptoms associated with neuropathic disorders such as hyperalgesia, allodynia, and parasthesias, using a l-aryl-3-azabicyclo[3.1.0] hexane. The invention further relates to the use of l-aryl-3-azabicyclo[3.1.0] hexanes in pharmaceutical compositions and methods for treating neuropathic disorders and related symptoms in mammals. Patients amenable to treatment according to the invention include those suffering from diabetic neuropathies, post-herpetic neuralgia, trigeminal neuralgia, chronic lower back pain, sciatica, idiopathic and post-traumatic neuropathies, HIV-associated neuropathic pain, among many other neuropathic disorders and related symptoms.
(FR)L'invention concerne de nouvelles compositions ainsi que des procédés permettant de traiter des symptômes associés à des troubles neuropathiques, par exemple hyperalgie, allodynie, et parasthésie, à l'aide de 1-aryl-3-azabicyclo[3.1.0] hexane. L'invention concerne également l'utilisation de 1-aryl-3-azabicyclo[3.1.0] hexanes dans des compositions pharmaceutiques et des procédés de traitement de troubles neuropathiques et de symptômes connexes chez les mammifères. Les patients pouvant faire l'objet de ce traitement selon l'invention sont notamment ceux qui souffrent de neuropathies diabétiques, de névralgie post-herpétique, de névralgie faciale, de douleurs lombaires, de sciatique, de neuropathies idiopathiques et post-traumatiques, de douleurs neuropathiques associées au VIH, entre bon nombre d'autres troubles neuropathiques et symptômes connexes.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)