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Pub. No.:    WO/2007/014212    International Application No.:    PCT/US2006/028833
Publication Date: 01.02.2007 International Filing Date: 25.07.2006
A61B 5/00 (2006.01)
Applicants: MASSACHUSETTS INSTITUTE OF TECHNOLOGY [US/US]; 77 Massachusetts Avenue, Cambridge, MA 02139-4307 (US) (For All Designated States Except US).
SCEPANOVIC, Obrad [--/US]; (US) (For US Only).
GARDECKI, Joseph [--/US]; (US) (For US Only).
FELD, Michael, S. [US/US]; (US) (For US Only)
Inventors: SCEPANOVIC, Obrad; (US).
GARDECKI, Joseph; (US).
FELD, Michael, S.; (US)
Agent: HOOVER, Thomas, O.; WEINGARTEN, SCHURGIN, GAGNEBIN & LEBOVICI, LLP, Ten Post Office Square, Boston, MA 02109 (US)
Priority Data:
60/702,248 25.07.2005 US
Abstract: front page image
(EN)The present invention relates to multimodal spectroscopy (MMS) as a clinical tool for the in vivo diagnosis of disease in humans. The MMS technology combines Raman and fluorescence spectroscopy. A preferred embodiment involves diagnosis cancer of the breast and of vulnerable atherosclerotic plaque, esophageal, colon, cervical and bladder cancer. MMS is used to provide a more comprehensive picture of the metabolic, biochemical and morphological state of a tissue than afforded by either Raman or fluorescence and reflectance spectroscopies alone.
(FR)La présente invention concerne l'utilisation de la spectroscopie multimodale (MMS) comme outil clinique pour le diagnostic in vivo d'une maladie chez des être humains. Cette technologie MMS combine la spectroscopie Raman et la spectroscopie par fluorescence. Un mode de réalisation préféré concerne le diagnostic du cancer du sein et les plaques d'athérosclérose vulnérables, ainsi que le cancer de l'oesophage, du côlon, du col de l'utérus et de la vessie. La spectroscopie multimodale permet d'obtenir une image plus complète de l'état métabolique, biochimique et morphologique d'un tissu que dans le cas d'une spectroscopie Raman, d'une spectroscopie par fluorescence et d'une spectroscopie par réflexion seule.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)