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Pub. No.:    WO/2007/013603    International Application No.:    PCT/JP2006/315010
Publication Date: 01.02.2007 International Filing Date: 28.07.2006
A61K 38/22 (2006.01), A61K 48/00 (2006.01), A61P 7/10 (2006.01), C07K 14/47 (2006.01), C12N 15/09 (2006.01), C12P 21/02 (2006.01), C12R 1/91 (2006.01)
Applicants: ANGES MG, INC. [JP/JP]; 7-15, Saitoasagi 7-chome, Ibaraki-shi, Osaka 5670085 (JP) (For All Designated States Except US).
OSAKA UNIVERSITY [JP/JP]; 1-1, Yamadaoka, Suita-shi, Osaka 5650871 (JP) (For All Designated States Except US).
MORISHITA, Ryuichi [JP/JP]; (JP) (For US Only).
KANEDA, Yasufumi [JP/JP]; (JP) (For US Only).
NAKAGAMI, Hironori [JP/JP]; (JP) (For US Only).
SAITO, Yukihiro [JP/JP]; (JP) (For US Only)
Inventors: MORISHITA, Ryuichi; (JP).
KANEDA, Yasufumi; (JP).
NAKAGAMI, Hironori; (JP).
SAITO, Yukihiro; (JP)
Agent: SHIMIZU, Hatsushi; Kantetsu Tsukuba Bldg. 6F 1-1-1, Oroshi-machi Tsuchiura-shi, Ibaraki 3000847 (JP)
Priority Data:
2005-219410 28.07.2005 JP
2006-148970 29.05.2006 JP
(JA) リンパ管新生促進剤
Abstract: front page image
(EN)It is found that HGF can activate the proliferation and migration of a lymphatic endothelial cell to promote the lymphangiogenesis. Based on this finding, a lymphangiogenesis promoter is provided which comprises HGF or a functionally equivalent protein or compound thereof as an active ingredient. Also provided is a method for promoting lymphangiogenesis comprising the step of topically administering HGF or a functionally equivalent protein thereof to a patient suffering from lymphatic edema.
(FR)La présente invention expose la découverte selon laquelle le HGF peut activer la prolifération et la migration d’une cellule lymphatique endothéliale afin de promouvoir la lymphangiogénèse. A partir de cette découverte, un promoteur de lymphangiogénèse est fourni, qui comprend le HGF ou une protéine fonctionnellement équivalente ou un composé de celle-ci en tant qu’ingrédient actif. La présente invention fournit également une méthode de promotion de la lymphangiogénèse comprenant l’étape d’administration locale de HGF ou d’une protéine équivalente fonctionnellement à celle-ci à un patient souffrant d’oedème lymphatique.
(JA) 本発明者らは、HGFがリンパ管内皮細胞の増殖および遊走を活性化し、リンパ管新生を促進させることを見出した。本発明はこのような知見に基づくものであり、本発明は、HGFまたはそれと機能的に同等なタンパク質もしくは化合物を活性成分として含有するリンパ管新生促進剤を提供する。本発明はまた、上記知見に基づいて、HGFまたはそれと機能的に同等なタンパク質をリンパ浮腫を有する患者の患部に局所投与する工程を含む、リンパ管新生を促進する方法を提供する。
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)