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Pub. No.: WO/2007/013576 International Application No.: PCT/JP2006/314947
Publication Date: 01.02.2007 International Filing Date: 21.07.2006
IPC:
G01N 33/574 (2006.01) ,C12Q 1/68 (2006.01)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
574
for cancer
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
Applicants: NAKAMURA, Yusuke[JP/JP]; JP (UsOnly)
FURUKAWA, Yoichi[JP/JP]; JP (UsOnly)
TAHARA, Hideaki[JP/JP]; JP (UsOnly)
TSUNODA, Takuya[JP/JP]; JP (UsOnly)
MATSUSHIMA, Satoshi[JP/JP]; JP (UsOnly)
ONCOTHERAPY SCIENCE, INC.[JP/JP]; 2-1, Sakado 3-chome, Takatsu-ku, Kawasaki-shi, Kanagawa 2130012, JP (AllExceptUS)
Inventors: NAKAMURA, Yusuke; JP
FURUKAWA, Yoichi; JP
TAHARA, Hideaki; JP
TSUNODA, Takuya; JP
MATSUSHIMA, Satoshi; JP
Agent: SHIMIZU, Hatsushi ; Kantetsu Tsukuba Bldg. 6F 1-1-1, Oroshi-machi Tsuchiura-shi Ibaraki 3000847, JP
Priority Data:
60/703,26527.07.2005US
Title (EN) COLON CANCER RELATED GENE TOM34
(FR) GENE TOM34 LIE AU CANCER DU COLON
Abstract:
(EN) Objective methods for detecting and diagnosing colon cancer are described herein. In one embodiment, the diagnostic method involves determining the expression level of TOM34 that discriminates between colon cancer cells and normal cells. Finally, the present invention provides methods of screening for therapeutic agents useful in the treatment of colon cancer, methods of treating colon cancer and method for vaccinating a subject against colon cancer.
(FR) La présente invention a trait à des procédés objectifs pour la détection et le diagnostic du cancer du côlon. Dans un mode de réalisation, le procédé de diagnostic comprend la détermination du niveau d'expression de TOM34 qui distingue des cellules du cancer du côlon des cellules normales. L'invention a trait enfin à des procédés de criblage pour des agents thérapeutiques utiles dans le traitement du cancer du côlon, à des procédés de traitement du cancer du côlon et à un procédé pour la vaccination d'un sujet contre le cancer du côlon.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)