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1. (WO2007013358) VIVIT POLYPEPTIDES, THERAPEUTIC AGENT COMPRISING THE SAME, AND METHOD OF SCREENING FOR ANTI-CANCER AGENT
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/013358    International Application No.:    PCT/JP2006/314442
Publication Date: 01.02.2007 International Filing Date: 14.07.2006
IPC:
C07K 7/04 (2006.01), C07K 7/08 (2006.01), C07K 14/435 (2006.01), A61K 38/17 (2006.01), A61K 38/10 (2006.01), C12N 15/62 (2006.01), G01N 33/50 (2006.01)
Applicants: ONCOTHERAPY SCIENCE, INC. [JP/JP]; 2-1, Sakado 3-chome, Takatsu-ku, Kawasaki-shi, Kanagawa, 2130012 (JP) (For All Designated States Except US).
NAKAMURA, Yusuke [JP/JP]; (JP) (For US Only).
KATAGIRI, Toyomasa [JP/JP]; (JP) (For US Only).
INAKI, Koichiro [JP/JP]; (JP) (For US Only)
Inventors: NAKAMURA, Yusuke; (JP).
KATAGIRI, Toyomasa; (JP).
INAKI, Koichiro; (JP)
Agent: SHIMIZU, Hatsushi; Kantetsu Tsukuba Bldg. 6F, 1-1-1, Oroshi-machi, Tsuchiura-shi, Ibaraki 3000847 (JP)
Priority Data:
60/703,791 28.07.2005 US
Title (EN) VIVIT POLYPEPTIDES, THERAPEUTIC AGENT COMPRISING THE SAME, AND METHOD OF SCREENING FOR ANTI-CANCER AGENT
(FR) POLYPEPTIDES VIVIT, AGENT THERAPEUTIQUE LES CONTENANT ET METHODE DE RECHERCHE PAR CRIBLAGE D'AGENT ANTICANCER
Abstract: front page image
(EN)The present invention provides polypeptides useful for treating and preventing cancer. The present invention also provides therapeutic agents or methods for treating cancer using the polypeptides. The polypeptides of the present invention are composed of an amino acid sequence which comprises VIVIT and is preferably a polypeptide in which the motif sequence PxIxIT at positions 37 to 41 of the amino acid sequence of the C1958 protein (SEQ ID NO: 2) is replaced with PVIVIT. The polypeptides of the present invention can be introduced into cancer cells by modifying the polypeptides with transfection agents such as poly-arginine. The present invention provides methods and kits for identifying inhibitors of the interaction between C1958 and PPP3CA which find utility in the treatment and prevention of cancer. Also disclosed herein are compositions for treating or preventing cancer identified by the screening method of the present invention and methods of using same in the treatment and prevention of cancer.
(FR)L'invention concerne des polypeptides utiles pour traiter et prévenir le cancer. Elle concerne également des agents thérapeutiques ou des méthodes servant à traiter le cancer au moyen de ces polypeptides. Ces derniers sont composés d'une séquence d'acides aminés comprenant VIVIT et présentent, de préférence, une séquence de motifs PxIxIT dans les positions 37 à 41 de la séquence amino-acide de la protéine C1958 (SEQ ID NO :2), qui est remplacée par PVIVIT. Leur introduction dans des cellules cancéreuses peut être effectuée par modification desdits polypeptides par des agents de transfection, tels que polyarginine. Elle concerne des méthodes et des trousses servant à identifier des inhibiteurs de l'interaction entre C1958 et PPP3CA et s'appliquant positivement en thérapie et prophylaxie du cancer. Elle concerne également des compositions servant à traiter ou à prévenir le cancer et identifiées au moyen d'une méthode de criblage, ainsi que des méthodes visant à utiliser ces compositions en traitement et prévention du cancer.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)