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1. (WO2007013147) ANGIOGENESIS INHIBITOR AND VASCULAR REGRESSIVE AGENT
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/013147    International Application No.:    PCT/JP2005/013713
Publication Date: 01.02.2007 International Filing Date: 27.07.2005
IPC:
A61K 31/198 (2006.01), A61K 38/00 (2006.01), A61P 27/02 (2006.01), A61P 37/08 (2006.01), A61P 35/00 (2006.01), G01N 33/15 (2006.01), G01N 33/50 (2006.01)
Applicants: InBiotex inc. [JP/JP]; Grace Imas Bldg, 24-2, Hongo 5-chome, Bunkyo-ku, T okyo 1130033 (JP) (For All Designated States Except US).
NATORI, Syunji [JP/JP]; (JP) (For US Only)
Inventors: NATORI, Syunji; (JP)
Agent: HAYAKAWA, Yuzi; Arcadia Patent Firm Suite 501 Hikawa-Annex No.2 9-5, Akasaka 6-chome Minato-ku, Tokyo 1070052 (JP)
Priority Data:
Title (EN) ANGIOGENESIS INHIBITOR AND VASCULAR REGRESSIVE AGENT
(FR) INHIBITEUR DE L’ANGIOGENÈSE ET AGENT DE RÉGRESSION VASCULAIRE
(JA) 血管新生阻害剤及び血管退縮剤
Abstract: front page image
(EN)Disclosed are a novel angiogenesis inhibitor and a novel vascular regressive agent. The angiogenesis inhibitor and the vascular regressive agent each comprise a 3,4-dihydroxyphenylalanine derivative such as N-&bgr;-alanyl-5-S-glutathionyl-3,4-dihydroxyphenylalanine, &bgr;-alanyl-3,4-dihydroxyphenylalanine and 5-S-cysteinyl-3,4-dihydroxyphenylalanine or a pharmaceutically acceptable salt thereof as the active ingredient.
(FR)La présente invention concerne un nouvel inhibiteur de l’angiogenèse et un nouvel agent de régression vasculaire. L’inhibiteur de l’angiogenèse et l’agent de régression vasculaire comprennent chacun un dérivé de la 3,4-dihydroxyphénylalanine tel que N-&bgr;-alanyl-5-S-glutathionyl-3,4-dihydroxyphénylalanine, &bgr;-alanyl-3,4-dihydroxyphénylalanine et 5-S-cystéinyl-3,4-dihydroxyphénylalanine ou un sel pharmaceutiquement acceptable de celui-ci en tant que principe actif.
(JA) 新規な血管新生阻害剤及び血管退縮剤を提供することを目的とし、この目的を達成するために、血管新生阻害剤及び血管退縮剤の有効成分として、N-β-アラニル-5-S-グルタチオニル-3,4-ジヒドロキシフェニルアラニン、β-アラニル-3,4-ジヒドロキシフェニルアラニン、5-S-システイニル-3,4-ジヒドロキシフェニルアラニン等の3,4-ジヒドロキシフェニルアラニン誘導体又はその薬学的に許容される塩を含有させる。
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)