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1. (WO2007013124) STIMULATORY AUTO-ANTIBODIES TO THE PDGF RECEPTOR AS PATHOLOGY MARKER AND THERAPEUTIC TARGET
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/013124    International Application No.:    PCT/IT2006/000587
Publication Date: 01.02.2007 International Filing Date: 28.07.2006
IPC:
G01N 33/564 (2006.01), A61K 38/18 (2006.01)
Applicants: AVVEDIMENTO, Vittorio Enrico [IT/IT]; (IT).
GABRIELLI, Armando [IT/IT]; (IT).
SANTILLO, Mariarosa [IT/IT]; (IT).
FUNARO, Ada [IT/IT]; (IT).
LUCHETTI, Michele [IT/IT]; (IT).
SVEGLIATI BARONI, Silvia [IT/IT]; (IT)
Inventors: AVVEDIMENTO, Vittorio Enrico; (IT).
GABRIELLI, Armando; (IT).
SANTILLO, Mariarosa; (IT).
FUNARO, Ada; (IT).
LUCHETTI, Michele; (IT).
SVEGLIATI BARONI, Silvia; (IT)
Agent: CAPASSO, Olga; De Simone & Partners S.p.A., Via Vincenzo Bellini 20, I-00198 Roma (IT)
Priority Data:
60/703,377 28.07.2005 US
Title (EN) STIMULATORY AUTO-ANTIBODIES TO THE PDGF RECEPTOR AS PATHOLOGY MARKER AND THERAPEUTIC TARGET
(FR) AUTO-ANTICORPS STIMULATEURS DU RECEPTEUR PDGF UTILISES COMME MARQUEUR PATHOLOGIQUE ET COMME CIBLE THERAPEUTIQUE
Abstract: front page image
(EN)An in vitro method for detecting the presence in a body sample of auto-antibodies for the PDGF receptor suitable for the diagnosis and prognosis of autoimmune diseases, in particular the systemic sclero-is and related diagnostic kits. Use of an inhibitor of ROS and/or Ras-ERK1/2 for the preparation of a medicament for therapeutic treatment of autoimmune diseases or of treating the Graft-Versus-Host- Reaction (GVHR). Pharmaceutical composition comprising an effective amount of an inhibitor of ROS and/or Ras-ERK1/2, and proper diluents, and /or excipients, and/or adjuvants.
(FR)L'invention porte sur une technique in vitro de détection de la présence, dans un échantillon du corps humain, d'auto-anticorps du récepteur PDGF convenant au diagnostic et au pronostic de maladies autoimmunes, en particulier de la sclérodermie systémique, ainsi que sur des kits diagnostics associés. L'invention porte également sur un inhibiteur de ROS et/ou de Ras-ERK1/2 utilisé dans la préparation d'un médicament destiné au traitement thérapeutique de maladies autoimmunes ou destiné au traitement des formes de réaction du greffon contre l'hôte (GVHR). L'invention porte également sur une composition pharmaceutique comprenant une dose efficace d'un inhibiteur de ROS et/ou de Ras-ERK1/2, de diluants appropriés, et/ou d'excipients et/ou d'adjuvants.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)