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1. (WO2007012974) CYCLODEXTRIN NANOTECHNOLOGY FOR OPHTHALMIC DRUG DELIVERY
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2007/012974 International Application No.: PCT/IB2006/002769
Publication Date: 01.02.2007 International Filing Date: 21.07.2006
IPC:
A61K 9/10 (2006.01) ,A61K 47/48 (2006.01) ,A61P 27/02 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
10
Dispersions; Emulsions
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
48
the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
27
Drugs for disorders of the senses
02
Ophthalmic agents
Applicants: LOFTSSON, Thorsteinn[IS/IS]; IS (UsOnly)
STEFANSSON, Einar[IS/IS]; IS (UsOnly)
OCULIS EHF[IS/IS]; Fjaröarási 13 IS-110 Reykjavik, IS (AllExceptUS)
Inventors: LOFTSSON, Thorsteinn; IS
STEFANSSON, Einar; IS
Agent: HEDLEY, Nicholas, James, Matthew; Kilburn & Strode 20 Red Lion Street London WC1R 4PJ, GB
Priority Data:
60/701,62122.07.2005US
60/795,56328.04.2006US
Title (EN) CYCLODEXTRIN NANOTECHNOLOGY FOR OPHTHALMIC DRUG DELIVERY
(FR) NANOTECHNOLOGIE A BASE DE CYCLODEXTRINE POUR ADMINISTRATION DE MEDICAMENTS OPHTALMIQUES
Abstract:
(EN) The invention provides an ophthalmic composition which is an aqueous suspension comprising drug, cyclodextrin and water, the composition having an aqueous phase of from about 0.1% (w/v) to about 90% (w/v) of the drug in solution, as dissolved free drug and as dissolved drug/cyclodextrin com&rgr;lex(es), and a solid phase of from about 10% (w/v) to about 99.9% (w/v) of the drug as solid drug/cyclodextrin particles, suspended in the aqueous phase; the size of the solid particles being from about 10 nm to about 1 mm, the drug/cyclodextrin particles being capable of dissolving in aqueous tear fluid within 24 hours of application to the eye surface. The aqueous eye suspension can be in the form of eye drops, eye gel or eye mist. Nasal compositions and ophthalmic and nasal compositions in powder form are also provided.
(FR) L'invention concerne une composition ophtalmique sous forme de suspension aqueuse comprenant un médicament, de la cyclodextrine et de l'eau. Cette composition possède une phase aqueuse comprise entre environ 0,1 % (p/v) et environ 90 % (p/v) du médicament en solution, en tant que médicament libre dissous et en tant que complexe(s) de médicament/cyclodextrine dissous; et une phase solide comprise entre environ 10 % (p/v) et environ 99.9 % (p/v) du médicament en tant que particules solides de médicament/cyclodextrine, en suspension dans la solution aqueuse. La taille des particules solides se situe entre 10 nm et 1 mm environ et les particules peuvent se dissoudre dans le liquide lacrymal aqueux dans les 24 heures suivant application sur la surface de l'oeil. Cette suspension ophtalmique aqueuse peut se présenter sous forme de gouttes, de gel ou de brumisation pour les yeux. Sont également décrites des compositions nasales et des compositions ophtalmiques et nasales.
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Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)