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1. (WO2007012970) GRADED EXPRESSION OF SNAIL AS MARKER OF CANCER DEVELOPMENT AND DNA DAMAGE-BASED DISEASES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/012970    International Application No.:    PCT/IB2006/002571
Publication Date: 01.02.2007 International Filing Date: 28.07.2006
IPC:
G01N 33/574 (2006.01), G01N 33/50 (2006.01), C12N 15/00 (2006.01), A01K 67/027 (2006.01), A61K 31/00 (2006.01), A61K 38/00 (2006.01), A61K 39/00 (2006.01)
Applicants: ONCOSTEM PHARMA, S.L. [ES/ES]; Plaza de Espana, 5-6, E-37004 Salamanca (ES) (For All Designated States Except US).
SANCHEZ-GARCIA, Isidro [ES/ES]; (ES) (For US Only).
VOCES, Felipe [ES/ES]; (ES) (For US Only).
PEREZ-MANCERA, Pedro, Antonio [ES/ES]; (ES) (For US Only)
Inventors: SANCHEZ-GARCIA, Isidro; (ES).
VOCES, Felipe; (ES).
PEREZ-MANCERA, Pedro, Antonio; (ES)
Agent: GOODFELLOW, Hugh, Robin; Carpmaels & Ransford, 43-45 Bloomsbury Square, London WC1A 2RA (GB)
Priority Data:
05076753.2 28.07.2005 EP
Title (EN) GRADED EXPRESSION OF SNAIL AS MARKER OF CANCER DEVELOPMENT AND DNA DAMAGE-BASED DISEASES
(FR) EXPRESSION GRADUEE DE SNAIL SERVANT DE MARQUEUR D'UN DEVELOPPEMENT CANCEREUX ET DE MALADIES CARACTERISEES PAR UNE LESION DE L'ADN
Abstract: front page image
(EN)The invention relates to the graded expression level of SNAIL gene or its expression products, as a marker of the capacity of epithelial and mesenchymal tumours and/or cancers for disseminating to other tissues or organs. The invention further relates to a transgenic non-human mammal comprising in its genome a transgene that comprises a nucleic acid sequence encoding the SNAIL protein, and the use of SNAIL as a marker of epithelial and mesenchymal tumours and/or cancers as well as in DNA damage-based diseases In addition, the invention relates to the use of SNAIL as a therapeutic and diagnostic target for said pathologies.
(FR)L'invention concerne un niveau d'expression gradué du gène SNAIL ou de ses produits d'expression. Ce niveau sert de marqueur de la capacité de développement de tumeurs épithéliales et mésenchymales et/ou de cancers, pour une dissémination sur d'autres tissus ou d'autres organes. L'invention concerne également un mammifère non humain transgénique comprenant, dans son génome, un transgène comprenant une séquence d'acide nucléique codant la protéine SNAIL. L'invention concerne également l'utilisation de SNAIL en tant que marqueur de tumeurs épithéliales et mésenchymales et/ou de cancers, ainsi que de maladies caractérisées par une lésion d'ADN. En outre, l'invention concerne l'utilisation de SNAIL en tant que cible thérapeutique et diagnostique pour les pathologies susmentionnées.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)