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Machine translation
1. (WO2007012334) IMPROVED PROTEIN EXPRESSION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/012334    International Application No.:    PCT/DK2005/000513
Publication Date: 01.02.2007 International Filing Date: 29.07.2005
IPC:
C12N 15/62 (2006.01), C12N 15/81 (2006.01)
Applicants: PHARMEXA A/S [DK/DK]; Kogle Allé 6, DK-2970 Hørsholm (DK) (For All Designated States Except US).
KJÆRULFF, Søren [DK/DK]; (DK) (For US Only)
Inventors: KJÆRULFF, Søren; (DK)
Agent: INSPICOS A/S; Boge Allé 5, P.O. Box 45, DK-2970 Hørsholm (DK)
Priority Data:
Title (EN) IMPROVED PROTEIN EXPRESSION
(FR) EXPRESSION DE PROTEINE AMELIOREE
Abstract: front page image
(EN)Disclosed is chimeric polynucleotides adopted for providing high-yield expression and secretion of recombinant polypeptides. The chimeric polynucleotide of the invention includes a functional secretion signal peptide derived from S. pombe carboxypeptidase Y (CPY). The invention also discloses methods for use of this cpy leader sequence.
(FR)L'invention concerne des polynucléotides chimériques adaptés pour fournir un haut rendement d'expression et de sécrétion de polypeptides recombinants. Le polynucléotide chimérique de l'invention compte un peptide de signalisation de sécrétion fonctionnel dérivé de la carboxypeptidase Y (CPY) de S. pombe. L'invention concerne aussi des méthodes d'utilisation de cette séquence de tête de CPY.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)