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1. WO2007012165 - STENTS COATED WITH NO- AND S-NITROSOTHIOL-ELUTING HYDROPHILIC POLYMERIC BLENDS

Publication Number WO/2007/012165
Publication Date 01.02.2007
International Application No. PCT/BR2006/000073
International Filing Date 19.04.2006
Chapter 2 Demand Filed 29.01.2007
IPC
A61L 27/54 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for prostheses or for coating prostheses
50Materials characterised by their function or physical properties
54Biologically active materials, e.g. therapeutic substances
CPC
A61L 2300/114
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
2300Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
10containing or releasing inorganic materials
114Nitric oxide, i.e. NO
A61L 2300/416
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
2300Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
40characterised by a specific therapeutic activity or mode of action
416Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
A61L 31/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
31Materials for other surgical articles ; , e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
08Materials for coatings
10Macromolecular materials
A61L 31/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
31Materials for other surgical articles ; , e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
14Materials characterised by their function or physical properties ; , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
16Biologically active materials, e.g. therapeutic substances
A61P 9/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
Applicants
  • SCI-TECH PRODUTOS MÈDICOS LTDA [BR]/[BR]
  • UNIVERSIDADE ESTADUAL DE CAMPINAS - UNICAMP [BR]/[BR]
  • GANZAROLLI DE OLIVEIRA, Marcelo [BR]/[BR] (UsOnly)
  • MARRA MOREIRA, Alexander [BR]/[BR] (UsOnly)
  • BAROZZI SEABRA, Amedea [BR]/[BR] (UsOnly)
  • MARTINS DE SOUZA GODOY SIMÕES, Maira [BR]/[BR] (UsOnly)
  • PENHA MORATO, Spero [BR]/[BR] (UsOnly)
Inventors
  • GANZAROLLI DE OLIVEIRA, Marcelo
  • MARRA MOREIRA, Alexander
  • BAROZZI SEABRA, Amedea
  • MARTINS DE SOUZA GODOY SIMÕES, Maira
  • PENHA MORATO, Spero
Agents
  • TAVARES PROPRIEDADE INTELECTUAL
Priority Data
PI0503201-628.07.2005BR
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) STENTS COATED WITH NO- AND S-NITROSOTHIOL-ELUTING HYDROPHILIC POLYMERIC BLENDS
(FR) ENDOPROTHÈSES VASCULAIRES RECOUVERTES DE MÉLANGES POLYMÉRIQUES HYDROPHILES LIBÉRANT NO ET DES S-NITROSOTHIOLS
Abstract
(EN) This invention relates to stents coated with hydrophilic polymers containing S-nitrosothiols, which are able to provide local delivery of both nitric oxide and S-nitrosothiols by diffusion. This device is intended for coronary angioplasty applications with the purpose of inhibiting acute and chronic restenosis and refers to processes of stent coating with hydrophilic polymers containing incorporated S-nitrosothiols. This invention refers to an intracoronary implant device used in medical procedures, and introduces new S nitrosothiol- eluting stents coated with hydrophilic polymer multilayers. The hydrophilic polymers used for coating are polyvinyl alcohol, polyvinylpirrolidone and polyvinyl alcohol/polyvinylpirrolidone, polyvinyl alcohol/polyethylene glycol, polyvinylpirrolidone/polyethylene glycol and polyvinyl alcohol/polyvinylpirrolidone/polyethylene glycol blends. The S-nitrosothiols incorporated to the polymer coatings are mainly primary S-nitrosothiols, characterized by the fact of the nitric oxide (NO) molecule being covalently bound to a sulfur (S) atom which, in turn, is linked to a primary carbon in the molecule's structure, thus constituting the S-NO chemical group. The coating processes include immersion of the stents in polymer solutions containing S- nitrosothiols and nebulization processes of the polymer solutions containing S- nitrosothiols onto the stent surface.
(FR) Cette invention concerne des endoprothèses vasculaires recouvertes de polymères hydrophiles contenant des S-nitrosothiols, lesquelles peuvent libérer localement à la fois de l'oxyde nitrique et des S-nitrosothiols par diffusion. Ce dispositif est destiné à des applications d'angioplastie coronarienne avec pour objectif d'inhiber une resténose aiguë et chronique et concerne des procédés de revêtement d'endoprothèses vasculaires par des polymères hydrophiles contenant des S-nitrosothiols incorporés. Cette invention concerne un dispositif d'implant intra-coronarien utilisé dans des procédures médicales et introduit de nouvelles endoprothèses vasculaires libérant des S-nitrosothiols recouvertes de multicouches de polymère hydrophile. Les polymères hydrophiles utilisés pour le revêtement sont l'alcool polyvinylique, la polyvinylpyrrolidone et des mélanges d'alcool polyvinylique/polyvinylpyrrolidone, d'alcool polyvinylique/polyéthylèneglycol, de polyvinylpyrrolidone/polyéthylèneglycol et d'alcool polyvinylique/polyvinylpyrrolidone/polyéthylèneglycol. Les S-nitrosothiols incorporés dans les revêtements de polymère sont principalement des S-nitrosothiols primaires, caractérisés en ce que la molécule d'oxyde nitrique (NO) est liée de façon covalente à un atome de soufre (S) lequel, à son tour, est lié à un carbone primaire dans la structure de la molécule, constituant ainsi le groupe chimique S-NO. Les procédés de revêtement comprennent l'immersion des endoprothèses vasculaires dans des solutions de polymère contenant des S-nitrosothiols et des procédés de pulvérisation des solutions de polymère contenant des S-nitrosothiols sur la surface des endoprothèses vasculaires.
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