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1. (WO2007012033) IL28 AND IL29 TRUNCATED CYSTEINE MUTANTS AND ANTIVIRAL METHODS OF USING SAME
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/012033    International Application No.:    PCT/US2006/028215
Publication Date: 25.01.2007 International Filing Date: 20.07.2006
IPC:
A61K 38/20 (2006.01), A61P 31/12 (2006.01)
Applicants: ZYMOGENETICS, INC. [US/US]; 1201 Eastlake Avenue East, Seattle, WA 98102 (US) (For All Designated States Except US).
SHEPPARD, Paul, O. [US/US]; (US) (For US Only)
Inventors: SHEPPARD, Paul, O.; (US)
Agent: WALSH, Brian, J.; 1201 Eastlake Avenue East, Seattle, WA 98102 (US)
Priority Data:
60/700,905 20.07.2005 US
Title (EN) IL28 AND IL29 TRUNCATED CYSTEINE MUTANTS AND ANTIVIRAL METHODS OF USING SAME
(FR) MUTANTS DE LA CYSTEINE TRONQUES IL28 ET IL29 ET PROCEDES ANTIVIRAUX METTANT EN OEUVRE CEUX-CI
Abstract: front page image
(EN)IL-28A, IL-28B, IL-29, and certain mutants thereof have been shown to have antiviral activity on a spectrum of viral species. Of particular interest is the antiviral activity demonstrated on viruses that infect liver, such as hepatitis B virus and hepatitis C virus. In addition, IL-28A, IL-28B, IL-29, and mutants thereof do not exhibit some of the antiproliferative activity on hematopoietic cells that is observed with interferon treatment. Without the immunosuppressive effects accompanying interferon treatment, IL-28A, IL-28B, and IL-29 will be useful in treating immunocompromised patients for viral infections.
(FR)L'invention concerne IL-28A, IL-28B, IL-29 et certains mutants de ceux-ci possédant une activité antivirale sur un spectre d'espèces virales. L'invention concerne spécialement l'activité antivirale démontrée sur des virus attaquant le foie, tels que les virus de l'hépatite B et de l'hépatite C. de plus, IL-28A, IL-28B, IL-29 et les mutants de ceux-ci ne possèdent pas une partie de l'activité anti-proliférative sur des cellules hématopoïétiques observée avec un traitement par interférons. Sans les effets immunosuppresseurs accompagnant le traitement par interférons, IL-28A, IL-28B et IL-29 seront utiles dans le traitement de patients immunodéprimés souffrant d'infections virales.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)