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Machine translation
1. (WO2007012004) TRANSPORT AGENTS FOR CROSSING THE BLOOD-BRAIN BARRIER AND INTO BRAIN CANCER CELLS, AND METHODS OF USE THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/012004    International Application No.:    PCT/US2006/028022
Publication Date: 25.01.2007 International Filing Date: 19.07.2006
Chapter 2 Demand Filed:    17.05.2007    
IPC:
C12P 21/04 (2006.01)
Applicants: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS [US/US]; 1853 West Polk Street, Suite 446, Chicago, IL 60612 (US) (For All Designated States Except US).
HONG, Chang [KR/US]; (US) (For US Only).
YAMADA, Tohru [JP/US]; (US) (For US Only).
FIALHO, Arsenio [PT/PT]; (PT) (For US Only).
DAS GUPTA, Tapas [US/US]; (US) (For US Only).
CHAKRABARTY, Ananda [US/US]; (US) (For US Only)
Inventors: HONG, Chang; (US).
YAMADA, Tohru; (US).
FIALHO, Arsenio; (PT).
DAS GUPTA, Tapas; (US).
CHAKRABARTY, Ananda; (US)
Agent: PELTO, Don; Sheppard Mullin Richter & Hampton LLP, 1300 I Street, NW, 11th Floor, Washington, DC 20005 (US)
Priority Data:
60/700,297 19.07.2005 US
11/244,105 06.10.2005 US
60/818,510 06.07.2006 US
Title (EN) TRANSPORT AGENTS FOR CROSSING THE BLOOD-BRAIN BARRIER AND INTO BRAIN CANCER CELLS, AND METHODS OF USE THEREOF
(FR) AGENTS DE TRANSPORT UTILES POUR TRAVERSER LA BARRIERE HEMATO-ENCEPHALIQUE ET POUR PENETRER DANS LES CELLULES CANCEREUSES DU CERVEAU, METHODES D'UTILISATION DE CES DERNIERS
Abstract: front page image
(EN)The present invention discloses methods and materials for delivering a cargo compound into a brain cancer cell and/or across the blood-brain barrier. Delivery of the cargo compound is accomplished by the use of protein transport peptides derived from Neisseria outer membrane proteins, such as Laz. The invention also provides synthetic transit peptides comprised of the pentapeptide AAEAP. The invention further discloses methods for treating cancer, and specifically brain cancer, as well as other brain-related conditions. Further, the invention provides methods of imaging and diagnosing cancer, particular brain cancer.
(FR)La présente invention concerne des méthodes et des matières utiles pour apporter un composé transporteur dans une cellule cancéreuse du cerveau et/ou à travers la barrière hémato-encéphalique. La livraison du composé transporteur est effectuée au moyen de peptides de transport de protéines dérivés de protéines de membrane externe Neisseria, telles que Laz. Cette invention se rapporte également à des peptides de transit synthétiques formés du pentapeptide AAEAP, à des méthodes de traitement du cancer et plus spécifiquement du cancer du cerveau, ainsi que d'autres pathologies liées au cerveau et enfin à des méthodes d'imagerie et de diagnostic du cancer, notamment du cancer du cerveau.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)