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1. (WO2007011985) COMPOSITIONS FOR THE REVERSIBLE THIOESTERIFICATION OF SIGNALING PROTEINS AND METHODS OF USING SAME
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/011985 International Application No.: PCT/US2006/027970
Publication Date: 25.01.2007 International Filing Date: 18.07.2006
IPC:
A61K 47/48 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
48
the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
Applicants:
DUKE UNIVERSITY [US/US]; 3100 Tower Boulevard Suite 1340 Durham, NC 27707, US (AllExceptUS)
RESEARCH DEVELOPMENT FOUNDATION [US/US]; 402 North Division Street Carson City, NV 89703, US (AllExceptUS)
STAMLER, Jonathan, S. [US/US]; US (UsOnly)
GUTTERMAN, Jordan [US/US]; US (UsOnly)
Inventors:
STAMLER, Jonathan, S.; US
GUTTERMAN, Jordan; US
Agent:
ELRIFI, Ivor, R.; Mintz, Levin, Cohn, Ferris, Glovsky and Popeo PC One Financial Center Boston, MA 02111, US
Priority Data:
60/700,11918.07.2005US
Title (EN) COMPOSITIONS FOR THE REVERSIBLE THIOESTERIFICATION OF SIGNALING PROTEINS AND METHODS OF USING SAME
(FR) COMPOSITIONS POUR LA THIOESTERIFICATION REVERSIBLE DE PROTEINES DE SIGNALISATION ET TECHNIQUES D'UTILISATION DE CELLES-CI
Abstract:
(EN) Avicins and other thioesterification agents are used to modify cysteine groups of signaling proteins in order to modify their activity. Pathologies associated with signaling proteins which are regulatable through this method are treated using these thioesterification agents. These pathologies include those involving proteins which modulate physiologic redox status of organisms including arthersclerosis, cancer, bacterial infection, inflammation, and neurological disorders.
(FR) On utilise des avicines et d'autres agents de thioesterification pour modifier des groupes cystéine de protéines de signalisation afin de modifier leur activité. Des pathologies associées aux protéines de signalisation qui peuvent être régulée par cette technique sont traitées au moyen de ces agents de thioesterification. Ces pathologies comprennent celles dans lesquelles entrent en jeu des protéines qui modulent l'état redox physiologique d'organismes, notamment l'artériosclérose, le cancer, l'infection bactérienne, l'inflammation et les troubles neurologiques.
front page image
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
CA2616589