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1. (WO2007011941) HUMAN ANTI-B7RP1 NEUTRALIZING ANTIBODIES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/011941 International Application No.: PCT/US2006/027862
Publication Date: 25.01.2007 International Filing Date: 18.07.2006
IPC:
C07K 16/28 (2006.01) ,A61P 37/00 (2006.01) ,A61P 11/06 (2006.01) ,A61K 39/395 (2006.01) ,G01N 33/68 (2006.01) ,G01N 33/577 (2006.01) ,C12N 15/13 (2006.01) ,C12N 5/10 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37
Drugs for immunological or allergic disorders
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11
Drugs for disorders of the respiratory system
06
Antiasthmatics
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68
involving proteins, peptides or amino acids
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
577
involving monoclonal antibodies
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
12
Genes encoding animal proteins
13
Immunoglobulins
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
10
Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
Applicants:
AMGEN INC. [US/US]; One Amgen Center Drive Thousand Oaks, CA 91320-1799, US (AllExceptUS)
MEDAREX INC. [US/US]; 707 State Road Princeton, NJ 08540, US (AllExceptUS)
SIU, Gerald [US/US]; US (UsOnly)
SHEN, Wenyan [CA/US]; US (UsOnly)
YOSHINAGA, Steven, Kiyoshi [US/US]; US (UsOnly)
HUANG, Haichun [US/US]; US (UsOnly)
Inventors:
SIU, Gerald; US
SHEN, Wenyan; US
YOSHINAGA, Steven, Kiyoshi; US
HUANG, Haichun; US
Agent:
DERRY, Jason, J.; MCDONNELL BOEHNEN HULBERT & BERGHOFF LLP 300 South Wacker Drive Suite 3100 Chicago, IL 60606, US
Priority Data:
60/700,26518.07.2005US
Title (EN) HUMAN ANTI-B7RP1 NEUTRALIZING ANTIBODIES
(FR) ANTICORPS NEUTRALISANTS ANTI-B7RP1 HUMAINS
Abstract:
(EN) This invention provides antibodies that interact with or bind to human B7 related protein-1 (B7RP1) and antibodies that bind to and neutralize the function of B7RP1 thereby. The invention also provides pharmaceutical compositions of said antibodies and methods for neutralizing B7RP1 function, and particularly for treating immune disorders (e.g., inappropriate immune response) by administering a pharmaceutically effective amount of anti-B7RPl antibodies. Methods of detecting the amount of B7RP1 in a sample using anti-B7RPl antibodies are also provided.
(FR) L'invention concerne des anticorps qui interagissent avec la protéine 1 apparentée à B7 (B7RP1) ou qui se lient à celle-ci, ainsi que des anticorps qui se lient à B7RP1 ou qui en neutralisent la fonction. L'invention concerne également des compositions pharmaceutiques de ces anticorps et des méthodes destinées à neutraliser la fonction de B7RP1, notamment pour le traitement de troubles immunitaires (par ex., réponse immunitaire inappropriée), par administration d'une dose pharmaceutiquement efficace d'anticorps anti-B7RP1. L'invention se rapporte en outre à des méthodes destinées à détecter la concentration de B7RP1 dans un échantillon au moyen d'anticorps anti-B7RP1.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
NO20080302NZ565192RSP-2016/0557UAa200801269MXMX/a/2008/000734KR1020080049014
IL188642SG164369EP1915398CR141/9745BRPI0614040ZA2008/01137
JP2009501549EP2388276EP2388277EP2397496EP2397497EP2397498
EP2397499IL218888IL218889IL218890IL218892IL218893
CN101321783CA2614972EA200800355CA2854576SG2014003909KR1020100101016
KR1020130023356KR1020140097582ES2572177NZ604090NZ625807AU2006270009
DK1915398AU2011265342AU2017200408AU2013203437IN229/KOLNP/2008PT1915398