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1. (WO2007011940) SUSTAINED RELEASE OF ANTIINFECTIVES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/011940 International Application No.: PCT/US2006/027859
Publication Date: 25.01.2007 International Filing Date: 19.07.2006
IPC:
A61K 9/127 (2006.01) ,A61K 47/44 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
10
Dispersions; Emulsions
127
Liposomes
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
44
Oils, fats or waxes according to more than one of groups A61K47/02-A61K47/42109
Applicants:
TRANSAVE, INC. [US/US]; Priceton Corporate Plaza 11 Deer Park Drive, Suite 117 Monmouth Junction, NJ 08852-1923, US (AllExceptUS)
BONI, Lawrence, T. [US/US]; US (UsOnly)
MILLER, Brian, S. [US/US]; US (UsOnly)
MALININ, Vladimir [RU/US]; US (UsOnly)
LI, Xingong [CN/US]; US (UsOnly)
Inventors:
BONI, Lawrence, T.; US
MILLER, Brian, S.; US
MALININ, Vladimir; US
LI, Xingong; US
Agent:
ARNOLD, Beth, E. ; Foley Hoag LLP 155 Seaport Boulevard Boston, MA 02210-2698, US
Priority Data:
11/185,44819.07.2005US
Title (EN) SUSTAINED RELEASE OF ANTIINFECTIVES
(FR) SUBSTANCES ANTI-INFECTIEUSES A LIBERATION LENTE
Abstract:
(EN) Provided are lipid antiinfective formulations substantially free of anionic lipids with a lipid to antiinfective ratio is about 1 :1 to about 4:1, and a mean average diameter of less than about 1 μm. Also provided is a method of preparing a lipid antiinfective formulation comprising an infusion process. Also provided are lipid antiinfective formulations wherein the lipid to drug ratio is about 1 : 1 or less, about 0.75:1 or less, or about 0.50:1 or less prepared by an in line fusion process. The present invention also relates to a method of treating a patient with a pulmonary infection comprising administering to the patient a therapeutically effective amount of a lipid antiinfective formulation of the present invention. The present invention also relates to a method of treating a patient for cystic fibrosis comprising administering to the patient a therapeutically effective amount of a lipid antiinfective formulation of the present invention.
(FR) L'invention concerne des formulations anti-infectieuses lipidiques sensiblement exemptes de lipides anioniques, qui présentent un rapport du lipide à la substance anti-infectieuse d'environ 1:1 à environ 4:1 et un diamètre moyen inférieur à environ 1 µm. L'invention concerne également une méthode de préparation d'une formulation anti-infectieuse lipidique comprenant un procédé d'infusion. Elle concerne aussi des formulations anti-infectieuses lipidiques dans lesquelles le rapport du lipide au médicament est d'au plus environ 1:1, d'au plus environ 0,75:1 ou d'au plus environ 0,50:1, et qui sont préparées par un procédé de fusion en ligne. L'invention concerne en outre une méthode de traitement d'un patient atteint d'une infection pulmonaire, qui consiste à administrer au patient une quantité thérapeutiquement efficace d'une formulation anti-infectieuse lipidique de l'invention. L'invention concerne enfin une méthode de traitement d'un patient atteint de mucoviscidose, qui consiste à administrer au patient une quantité thérapeutiquement efficace d'une formulation anti-infectieuse lipidique de l'invention.
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Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
RSP-2008/0019MXMX/a/2008/000425KR1020080027888IL188406EP1909759ZA2008/00367
JP2009502794IL216401RU0002438655CN101267806CA2614764EP2649988
ES2437866KR1020140013055IL246026NZ565300AU2006270008DK1909759
IN353/DELNP/2008