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1. (WO2007011905) LPA2 RECEPTOR AGONIST INHIBITORS OF CFTR
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/011905 International Application No.: PCT/US2006/027765
Publication Date: 25.01.2007 International Filing Date: 19.07.2006
IPC:
A61K 31/685 (2006.01) ,A61K 31/665 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
66
Phosphorus compounds
683
Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
685
one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
66
Phosphorus compounds
665
having oxygen as a ring hetero atom, e.g. fosfomycin
Applicants:
THE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION [US/US]; 1534 White Avenue, Suite 403 Knoxville, Tennessee 37996-1527, US (AllExceptUS)
NAREN, Anjaparavanda [IN/US]; US (UsOnly)
LI, Chunying [CN/US]; US (UsOnly)
DENG, Wenlin [CN/US]; US (UsOnly)
JOHNSON, Leonard [US/US]; US (UsOnly)
DURGAM, Gangadhar [IN/US]; US (UsOnly)
MILLER, Duane [US/US]; US (UsOnly)
TIGYI, Gabor [US/US]; US (UsOnly)
Inventors:
NAREN, Anjaparavanda; US
LI, Chunying; US
DENG, Wenlin; US
JOHNSON, Leonard; US
DURGAM, Gangadhar; US
MILLER, Duane; US
TIGYI, Gabor; US
Agent:
RUSSELL, Donna; 1492 Anthony Way Mt. Juliet, Tennessee 37122, US
Priority Data:
60/700,48919.07.2005US
Title (EN) LPA2 RECEPTOR AGONIST INHIBITORS OF CFTR
(FR) INHIBITEUR D'UN AGONISTE DU RECEPTEUR LPA2 DE CFTR
Abstract:
(EN) Methods and compositions for treating or preventing diarrhea are disclosed. The methods comprise administering to an individual a therapeutically effective amount of an LPA2 receptor agonist for treating or preventing diarrhea. Also disclosed is a method of inhibiting CFTR activation by administering at least one LPA2 receptor agonist in an amount effective to inhibit formation of a macromolecular complex between the LPA2 receptor, CFTR, and a Na+/H+ exchange regulatory factor-2 (NHERF-2).
(FR) L'invention concerne des procédés et compositions permettant de traiter ou de prévenir la diarrhée. Ces procédés consistent à administrer à un patient une quantité thérapeutiquement efficace d'un agoniste du récepteur LPA2 pour traiter ou prévenir la diarrhée. L'invention concerne également un procédé d'inhibition de l'activation de CFTR par l'administration d'au moins un agoniste du récepteur LPA2 en quantité efficace pour inhiber la formation d'un complexe macromoléculaire entre le récepteur LPA2, CFTR et un facteur-2 de régulation de l'échange Na+/H+ (NHERF-2).
front page image
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
IL188820EP1906972JP2009502790CA2615836AU2006270066DK1906972