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1. (WO2007011833) SPIROPIPERIDINE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/011833    International Application No.:    PCT/US2006/027594
Publication Date: 25.01.2007 International Filing Date: 14.07.2006
IPC:
C07D 471/10 (2006.01), A61K 31/438 (2006.01), A61P 25/28 (2006.01)
Applicants: MERCK & CO., INC. [US/US]; 126 East Lincoln Avenue, Rahway, NJ 07065-0907 (US) (For All Designated States Except US).
SUNESIS PHARMACEUTICALS, INC. [US/US]; 341 Oyster Point Boulevard, South San Francisco, CA 94080 (US) (For All Designated States Except US).
COBURN, Craig, A. [US/US]; (US) (For US Only).
EGBERTSON, Melissa, S. [US/US]; (US) (For US Only).
GRAHAM, Samuel, L. [US/US]; (US) (For US Only).
MCGAUGHEY, Georgia, B. [US/US]; (US) (For US Only).
STAUFFER, Shaun, R. [US/US]; (US) (For US Only).
RAJAPAKSE, Hemaka, A. [LK/US]; (US) (For US Only).
NANTERMET, Philippe, G. [US/US]; (US) (For US Only).
STACHEL, Shawn, R. [US/US]; (US) (For US Only).
YANG, Wenjin [US/US]; (US) (For US Only).
LU, Wanli [CA/US]; (US) (For US Only).
FAHR, Bruce [US/US]; (US) (For US Only)
Inventors: COBURN, Craig, A.; (US).
EGBERTSON, Melissa, S.; (US).
GRAHAM, Samuel, L.; (US).
MCGAUGHEY, Georgia, B.; (US).
STAUFFER, Shaun, R.; (US).
RAJAPAKSE, Hemaka, A.; (US).
NANTERMET, Philippe, G.; (US).
STACHEL, Shawn, R.; (US).
YANG, Wenjin; (US).
LU, Wanli; (US).
FAHR, Bruce; (US)
Common
Representative:
MERCK & CO., INC.; 126 East Lincoln Avenue, Rahway, NJ 07065-0907 (US)
Priority Data:
60/700,090 18.07.2005 US
Title (EN) SPIROPIPERIDINE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE
(FR) INHIBITEURS DE SPIROPIPERIDINE BETA-SECRETASE POUR LE TRAITEMENT DE LA MALADIE D'ALZHEIMER
Abstract: front page image
(EN)The present invention is directed to spiropiperidine compounds of formula (I) and tautomers thereof, which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
(FR)Cette invention concerne des composés de spiropipéridine représentés par la formule (I) et des tautomères de ces composés, qui constituent des inhibiteurs de l'enzyme bêta-sécrétase et qui sont utiles dans le traitement des maladies dans lesquelles l'enzyme bêta-sécrétase est impliquée, telles que la maladie d'Alzheimer. Cette invention concerne également des compositions pharmaceutiques comprenant ces composés et l'utilisation de ces composés et de ces compositions dans le traitement des maladies dans lesquelles l'enzyme bêta-sécrétase est impliquée.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)