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1. (WO2007011820) ARYL-AND HETEROARYL-SUBSTITUTED TETRAHYDROBENZAZEPINES AND USE THEREOF TO BLOCK REUPTAKE OF NOREPINEPHRINE, DOPAMINE, AND SEROTONIN
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/011820 International Application No.: PCT/US2006/027574
Publication Date: 25.01.2007 International Filing Date: 17.07.2006
IPC:
A61P 25/00 (2006.01) ,A61K 31/55 (2006.01) ,C07D 223/16 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
55
having seven-membered rings, e.g. azelastine, pentylenetetrazole
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
223
Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
14
condensed with carbocyclic rings or ring systems
16
Benzazepines; Hydrogenated benzazepines
Applicants:
AMR TECHNOLOGY, INC. [US/US]; 5429 Main Street P.O. Box 2587 Manchester Center, VT 05255-2587, US (AllExceptUS)
BRISTOL-MYERS SQUIBB COMPANY [US/US]; Lawrenceville-Princeton Road Princeton, VT 05255-2587, US (AllExceptUS)
Inventors:
MOLINO, Bruce, F.; US
LIU, Shuang; US
SAMBANDAM, Aruna; US
GUZZO, Peter, R.; US
HU, Min; US
ZHA, Congxiang; US
NACRO, Kassoum; US
MANNING, David, D.; US
ISHERWOOD, Matthew, L.; US
FLEMING, Kristen, N.; US
CUI, Wenge; US
OLSON, Richard, E.; US
Agent:
CHOI, Alice, Y. ; Nixon Peabody LLP Clinton Square P.O. Box 31051 Rochester, NY 14603-1051, US
Priority Data:
60/700,05715.07.2005US
Title (EN) ARYL-AND HETEROARYL-SUBSTITUTED TETRAHYDROBENZAZEPINES AND USE THEREOF TO BLOCK REUPTAKE OF NOREPINEPHRINE, DOPAMINE, AND SEROTONIN
(FR) TETRAHYDROBENZAZEPINES SUBSTITUEES PAR ARYLE ET HETEROARYLE, ET LEUR UTILISATION POUR BLOQUER LA REABSORPTION DE LA NORADRENALINE, DE LA DOPAMINE, ET DE LA SEROTONINE
Abstract:
(EN) The compounds of the present invention are represented by the following aryl- and heteroaryl-substituted tetrahydrobenzazepine and dihydrobenzazapine derivatives having formulae I(A-E) and formula (II) where the carbon atom designated * is in the R or S configuration, and the substituents X and R1-R9 are as defined herein.
(FR) Les composés de l'invention sont représentés par la tétrahydrobenzazépine substituée par aryle et hétéroaryle et par des dérivés de dihydrobenzazapine de formules (I)(A-E) et de formule (II), dans lesquelles l'atome de carbone désigné* se trouve dans la configuration R ou S, et les substituants X et R1-R9 sont tels que définis dans le mémorandum descriptif.
front page image
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
UAa200801920MXMX/a/2008/000717VN17158KR1020080044840IL188758EP1904069
BRPI0613403ZA2008/00440JP2009508807IL216247IL221326JP2013006867
CN101495184CA2615403EA200800341KR1020140018388KR1020150023900NZ565111
AU2006270071AU2012202570VN25004ID2015/02958PH1/2014/501033IN237/CHENP/2008
GEP20125566B