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1. (WO2007011811) SPIROCHROMANONE DERIVATIVES AS ACETYL COENZYME A CARBOXYLASE (ACC) INHIBITORS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/011811 International Application No.: PCT/US2006/027546
Publication Date: 25.01.2007 International Filing Date: 14.07.2006
IPC:
C07D 491/10 (2006.01) ,C07D 495/10 (2006.01) ,A61K 31/438 (2006.01) ,A61P 3/00 (2006.01) ,A61P 35/00 (2006.01) ,A61P 31/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
491
Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/-C07D459/290
02
in which the condensed system contains two hetero rings
10
Spiro-condensed systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
495
Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
02
in which the condensed system contains two hetero rings
10
Spiro-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
438
the ring being spiro-condensed with carbocyclic or heterocyclic ring systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3
Drugs for disorders of the metabolism
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
Applicants:
MERCK & CO., INC. [US/US]; 126 East Lincoln Avenue Rahway, New Jersey 07065-0907, US (AllExceptUS)
BANYU PHARMACEUTICAL CO., LTD. [JP/JP]; Kitanomaru Square, 1-13-12 Kudankita, Chiyoda-ku, Tokyo 102-8667, JP (AllExceptUS)
YAMAKAWA, Takeru [JP/JP]; JP (UsOnly)
JONA, Hideki [JP/JP]; JP (UsOnly)
NIIYAMA, Kenji [JP/JP]; JP (UsOnly)
YAMADA, Koji [JP/JP]; JP (UsOnly)
IINO, Tomoharu [JP/JP]; JP (UsOnly)
OHKUBO, Mitsuru [JP/JP]; JP (UsOnly)
IMAMURA, Hideaki [JP/JP]; JP (UsOnly)
KUSUNOKI, Jun [JP/JP]; JP (UsOnly)
YANG, Lihu [US/US]; US (UsOnly)
Inventors:
YAMAKAWA, Takeru; JP
JONA, Hideki; JP
NIIYAMA, Kenji; JP
YAMADA, Koji; JP
IINO, Tomoharu; JP
OHKUBO, Mitsuru; JP
IMAMURA, Hideaki; JP
KUSUNOKI, Jun; JP
YANG, Lihu; US
Common
Representative:
MERCK & CO., INC.; 126 East Lincoln Avenue Rahway, New Jersey 07065-0907, US
Priority Data:
60/700,38219.07.2005US
Title (EN) SPIROCHROMANONE DERIVATIVES AS ACETYL COENZYME A CARBOXYLASE (ACC) INHIBITORS
(FR) DERIVES DE SPIROCHROMANONE UTILISES COMME INHIBITEURS DE CARBOXYLASE DE COENZYME D'ACETYLE (ACC)
Abstract:
(EN) The invention relates to a compound of a formula (I): or a pharmaceutically acceptable salt or ester thereof, useful as a therapeutic agent for various ACC-related disorders.
(FR) L'invention concerne un composé d'une formule (I) ou d'un sel ou ester correspondant pharmaceutiquement acceptable, utile en tant qu'agent thérapeutique pour de divers troubles associés à ACC.
front page image
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
NO20080865MXMX/a/2008/000966KR1020080036041IL188417AR054842PE2007-0527
DOP2006000170ZA2007/11119JP2009502785RU0002422446BRPI0613427CN101238132
CA2614963NZ564591AU2006270145MYPI 20063401TH86044IN101/DELNP/2008