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1. (WO2007011810) SPIROPIPERIDINE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/011810 International Application No.: PCT/US2006/027544
Publication Date: 25.01.2007 International Filing Date: 14.07.2006
IPC:
C07D 471/10 (2006.01) ,A61K 31/438 (2006.01) ,A61P 25/28 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
10
Spiro-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
438
the ring being spiro-condensed with carbocyclic or heterocyclic ring systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
28
for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Applicants:
MERCK & CO., INC. [US/US]; 126 East Lincoln Avenue Rahway, New Jersey 07065-0907, US (AllExceptUS)
SUNESIS PHARMACEUTICALS, INC. [US/US]; 341 Oyster Point Boulevard South San Francisco, California 94080, US (AllExceptUS)
COBURN, Craig, A. [US/US]; US (UsOnly)
EGBERTSON, Melissa, S. [US/US]; US (UsOnly)
GRAHAM, Samuel, L. [US/US]; US (UsOnly)
MCGAUGHEY, Georgia, B. [US/US]; US (UsOnly)
STAUFFER, Shaun, R. [US/US]; US (UsOnly)
YANG, Wenjin [US/US]; US (UsOnly)
LU, Wanli [CA/US]; US (UsOnly)
FAHR, Bruce [US/US]; US (UsOnly)
Inventors:
COBURN, Craig, A.; US
EGBERTSON, Melissa, S.; US
GRAHAM, Samuel, L.; US
MCGAUGHEY, Georgia, B.; US
STAUFFER, Shaun, R.; US
YANG, Wenjin; US
LU, Wanli; US
FAHR, Bruce; US
Common
Representative:
MERCK & CO., INC.; 126 East Lincoln Avenue Rahway, New Jersey 07065-0907, US
Priority Data:
60/700,09018.07.2005US
Title (EN) SPIROPIPERIDINE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE
(FR) INHIBITEURS DE BETA-SECRETASE DE SPIROPIPERIDINE DESTINES AU TRAITEMENT DE LA MALADIE D'ALZHEIMER
Abstract:
(EN) The present invention is directed to spiropiperidine compounds of formula (I) and tautomers thereof, which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of diseases in which the beta-secretase enzyme is involved.
(FR) La présente invention concerne des composés à base de spiropipéridine ayant la formule (I) et leurs tautomères, qui sont des inhibiteurs de l'enzyme bêta-secrétase utiles pour traiter des maladies dans lesquelles est impliquée l'enzyme bêta-secrétase telles que la maladie d'Alzheimer's. L'invention concerne aussi des compositions pharmaceutiques comprenant ces composés et l'utilisation de ces composés et compositions dans le traitement de maladies dans lesquelles est impliquée l'enzyme bêta-secrétase.
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Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)