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1. (WO2007011757) USE OF INHIBITORS OF THE UBIQUITIN PROTEASOME PATHWAY FOR INCREASING CONTRACTILITY OF THE HEART
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/011757 International Application No.: PCT/US2006/027443
Publication Date: 25.01.2007 International Filing Date: 12.07.2006
IPC:
A61K 38/06 (2006.01) ,A61P 9/04 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
04
Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
06
Tripeptides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
04
Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
Applicants:
MYOGEN, INC. [US/US]; 7575 W. 103rd Avenue, #102 Westminster, CO 80021-5426, US (AllExceptUS)
BUSH, Erik [US/US]; US (UsOnly)
GORCZYNSKI, Rick [US/US]; US (UsOnly)
KOCH, Keith [US/US]; US (UsOnly)
MCKINSEY, Timothy, A. [US/US]; US (UsOnly)
Inventors:
BUSH, Erik; US
GORCZYNSKI, Rick; US
KOCH, Keith; US
MCKINSEY, Timothy, A.; US
Agent:
HIGHLANDER, Steven, L.; FULBRIGHT & JAWORSKI L.L.P. 600 Congress Avenue Suite 2400 Austin, TX 78701, US
Priority Data:
60/699,18914.07.2005US
Title (EN) USE OF INHIBITORS OF THE UBIQUITIN PROTEASOME PATHWAY FOR INCREASING CONTRACTILITY OF THE HEART
(FR) UTILISATION D'INHIBITEURS DE LA VOIE UBIQUITINE-PROTEASOME POUR AUGMENTER LA CONTRACTILITE CARDIAQUE
Abstract:
(EN) The present invention describes novel uses for inhibitors of the ubiquitin proteasome degradative pathway. In particular it describes methods for improving cardiac function, increasing alpha myosin levels in the heart, and increasing SERCA levels in the heart. The invention also provides methods for treating cardiac hypertrophy through inhibiton of the ubiquitin proteasome.
(FR) L'invention concerne de nouvelles utilisations d'inhibiteurs de la voie de dégradation ubiquitine-protéasome. L'invention se rapporte, en particulier, à des procédés qui permettent d'améliorer la fonction cardiaque, d'augmenter les niveaux de myosine alpha dans le coeur, et d'augmenter les niveaux de la SERCA dans le coeur. L'invention porte également sur des procédés qui permettent de traiter l'hypertrophie cardiaque en inhibant l'ubiquitine-protéasome.
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Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP1901764CA2614959