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1. (WO2007011757) USE OF INHIBITORS OF THE UBIQUITIN PROTEASOME PATHWAY FOR INCREASING CONTRACTILITY OF THE HEART
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/011757    International Application No.:    PCT/US2006/027443
Publication Date: 25.01.2007 International Filing Date: 12.07.2006
IPC:
A61K 38/06 (2006.01), A61P 9/04 (2006.01)
Applicants: MYOGEN, INC. [US/US]; 7575 W. 103rd Avenue, #102, Westminster, CO 80021-5426 (US) (For All Designated States Except US).
BUSH, Erik [US/US]; (US) (For US Only).
GORCZYNSKI, Rick [US/US]; (US) (For US Only).
KOCH, Keith [US/US]; (US) (For US Only).
MCKINSEY, Timothy, A. [US/US]; (US) (For US Only)
Inventors: BUSH, Erik; (US).
GORCZYNSKI, Rick; (US).
KOCH, Keith; (US).
MCKINSEY, Timothy, A.; (US)
Agent: HIGHLANDER, Steven, L.; FULBRIGHT & JAWORSKI L.L.P., 600 Congress Avenue, Suite 2400, Austin, TX 78701 (US)
Priority Data:
60/699,189 14.07.2005 US
Title (EN) USE OF INHIBITORS OF THE UBIQUITIN PROTEASOME PATHWAY FOR INCREASING CONTRACTILITY OF THE HEART
(FR) UTILISATION D'INHIBITEURS DE LA VOIE UBIQUITINE-PROTEASOME POUR AUGMENTER LA CONTRACTILITE CARDIAQUE
Abstract: front page image
(EN)The present invention describes novel uses for inhibitors of the ubiquitin proteasome degradative pathway. In particular it describes methods for improving cardiac function, increasing alpha myosin levels in the heart, and increasing SERCA levels in the heart. The invention also provides methods for treating cardiac hypertrophy through inhibiton of the ubiquitin proteasome.
(FR)L'invention concerne de nouvelles utilisations d'inhibiteurs de la voie de dégradation ubiquitine-protéasome. L'invention se rapporte, en particulier, à des procédés qui permettent d'améliorer la fonction cardiaque, d'augmenter les niveaux de myosine alpha dans le coeur, et d'augmenter les niveaux de la SERCA dans le coeur. L'invention porte également sur des procédés qui permettent de traiter l'hypertrophie cardiaque en inhibant l'ubiquitine-protéasome.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)