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Machine translation
1. (WO2007011746) HIGHLY SENSITIVE IMMUNOASSAYS AND ANTIBODIES FOR DETECTION OF BLOOD FACTOR VIII
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/011746    International Application No.:    PCT/US2006/027409
Publication Date: 25.01.2007 International Filing Date: 13.07.2006
IPC:
A61K 39/395 (2006.01), A61K 35/14 (2006.01)
Applicants: THE UNIVERSITY OF VERMONT AND STATE AGRICULTURE COLLEGE [US/US]; College of Medicine, E109 Health Science Complex, 340 Waterman Bldg., Burlington, VT 05405 (US) (For All Designated States Except US).
PARHAMI-SEREN, Behnaz [US/US]; (US) (For US Only).
MANN, Kenneth, G. [US/US]; (US) (For US Only).
FASS, David, N. [US/CA]; (US) (For US Only)
Inventors: PARHAMI-SEREN, Behnaz; (US).
MANN, Kenneth, G.; (US).
FASS, David, N.; (US)
Agent: MCLAREN, Margaret, J.; Edwards Angell Palmer & Dodge LLP, P.O. Box 55874, Boston, MA 02205 (US)
Priority Data:
60/699,584 15.07.2005 US
60/715,978 09.09.2005 US
Title (EN) HIGHLY SENSITIVE IMMUNOASSAYS AND ANTIBODIES FOR DETECTION OF BLOOD FACTOR VIII
(FR) IMMUNOESSAIS ULTRASENSIBLES ET ANTICORPS POUR DETECTION DU FACTEUR VIII SANGUIN
Abstract: front page image
(EN)Disclosed are antibodies that selectively bind to blood coagulation factor FVIII and highly sensitive immunological assays comprising these antibodies. Preferred assays can detect FVIII at about 3500-fold below the normal physiological levels, and have a wide array of applications including accurate monitoring of FVIII concentration in pharmaceutical products for treatment of blood coagulation disorders, and determination of FVIII levels in plasma of human patients, including those with blood coagulation disorders such as hemophilia.
(FR)L'invention concerne des anticorps qui se lient sélectivement avec le facteur VIII de la coagulation du sang et des essais immunologiques ultrasensibles contenant ces anticorps. Les essais préférés sont capables de détecter le FVIII à des taux 3500 fois inférieurs aux taux physiologiques normaux, et présentent un large éventail d'applications, notamment le contrôle précis de la concentration de FVIII dans les produits pharmaceutiques destinés au traitement des troubles de la coagulation sanguine, et la détermination des taux de FVIII dans le plasma de patients humains, notamment ceux présentant des troubles de la coagulation sanguine tels que l'hémophilie.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)