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Machine translation
1. (WO2007011720) CYCLOPENTANE N-LOWER ALKYL HEPTENAMIDE-5-CIS-2- (3ALAPHA- HYDROXY-5-PHENYLPENTYL) -3, ?5-DIHYDROXY, [1ALPHA, 2BETA, 3ALPHA, 5ALPHA] COMPOUNDS AS AGENTS FOR LOWERING INTRAOCULAR PRESSURE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/011720    International Application No.:    PCT/US2006/027351
Publication Date: 25.01.2007 International Filing Date: 14.07.2006
IPC:
A61K 31/5575 (2006.01), A61P 27/06 (2006.01)
Applicants: ALLERGAN, INC. [US/US]; 2525 Dupont Drive, Irvine, CA 92612 (US) (For All Designated States Except US).
VOET, Martin, A. [US/US]; (US) (For US Only)
Inventors: VOET, Martin, A.; (US)
Agent: BARAN, Robert, J.; c/o Allergan, Inc., 2525 Dupont Drive, Irvine, CA 92612 (US)
Priority Data:
60/699,813 14.07.2005 US
Title (EN) CYCLOPENTANE N-LOWER ALKYL HEPTENAMIDE-5-CIS-2- (3ALAPHA- HYDROXY-5-PHENYLPENTYL) -3, ?5-DIHYDROXY, [1ALPHA, 2BETA, 3ALPHA, 5ALPHA] COMPOUNDS AS AGENTS FOR LOWERING INTRAOCULAR PRESSURE
(FR) COMPOSES DE CYCLOPENTANE N ALKYLE INFERIEUR HEPTENAMIDE-5-CIS-2- (3A- HYDROXY-5-PHENYLPENTYL) -3, 5-DIHYDROXY, [1A,2B,3A,5A] UTILISES EN TANT QU'AGENTS D'ABAISSEMENT DE LA PRESSION INTRAOCULAIRE
Abstract: front page image
(EN)The present invention provides a method of treating ocular hypertension or glaucoma which comprises administering to an animal having ocular hypertension or glaucoma therapeutically effective amount of a compound represented by the general formula I; wherein R is a lower alkyl radical, i.e. a C1-C6 alkyl radical, e.g. a methyl, ethyl or propyl radical. Most preferably said compound is (Z)-7-[lR, 2R, 2R, 5S)-3,5-Dihydroxy-2-[lE, 3S)-3-hydroxy-5-phenyl-l-pentyl]cyclopentyl]-5-N-ethylheptanamide.
(FR)La présente invention concerne une méthode de traitement de l'hypertension oculaire ou du glaucome qui consiste à administrer à un animal présentant de l'hypertension oculaire ou un glaucome une quantité thérapeutiquement efficace d'un composés représenté par la formule générale I, dans laquelle R désigne un radical alkyle, c.-à-d., un radical alkyle C1-C6, par ex., un radical méthyle, éthyle ou propyle. Idéalement, ledit composé est du (Z)-7-[1R, 2R, 2R, 5S)-3,5-dihydroxy-2-[1E, 3S)-3-hydroxy-5-phényl-l-pentyl]cyclopentyl]-5-N-éthylheptanamide.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)