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Machine translation
1. (WO2007011623) QUINAZOLINE DERIVATIVES USEFUL IN CANCER TREATMENT
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/011623    International Application No.:    PCT/US2006/027114
Publication Date: 25.01.2007 International Filing Date: 13.07.2006
IPC:
C07D 239/94 (2006.01), C07D 401/04 (2006.01), C07D 403/04 (2006.01), C07D 401/12 (2006.01), C07D 403/12 (2006.01), C07D 405/12 (2006.01), C07D 409/12 (2006.01), C07D 413/12 (2006.01), C07D 417/12 (2006.01), A61K 31/495 (2006.01)
Applicants: SCHERING CORPORATION [US/US]; 2000 Galloping Hill Road, Kenilworth, New Jersey 07033-0530 (US) (For All Designated States Except US).
MALLAMS, Alan, K. [US/US]; (US) (For US Only).
DASMAHAPATRA, Bimalendu [US/US]; (US) (For US Only).
NEUSTADT, Bernard, R. [US/US]; (US) (For US Only).
DEMMA, Mark [US/US]; (US) (For US Only).
VACCARO, Henry, A. [US/US]; (US) (For US Only)
Inventors: MALLAMS, Alan, K.; (US).
DASMAHAPATRA, Bimalendu; (US).
NEUSTADT, Bernard, R.; (US).
DEMMA, Mark; (US).
VACCARO, Henry, A.; (US)
Agent: BANERJEE, Krishna, G.; Schering-plough Corporation, 2000 Galloping Hill Road, Patent Dept. K-6-1 1990, Kenilworth, New Jersey 07033-0530 (US)
Priority Data:
60/700,058 15.07.2005 US
Title (EN) QUINAZOLINE DERIVATIVES USEFUL IN CANCER TREATMENT
(FR) DERIVES DE QUINAZOLINE UTILES POUR TRAITER LE CANCER
Abstract: front page image
(EN)The present invention provides compounds of Formula I (wherein X, m, R1, R2, R3, and R4 are as defined herein), or a pharmaceutically acceptable salt, solvate or ester thereof. The present invention also provides compositions comprising these compounds that are useful for treating cellular proliferative diseases, disorders associated with activity of mutants of p53, or in causing apoptosis of cancer cells.
(FR)La présente invention concerne des composés de formule I (dans laquelle X, m, R1, R2, R3, et R4 sont tels que définis dans l'invention), ou un sel, solvate ou ester de ceux-ci, acceptable d'un point de vue pharmaceutique. L'invention a également pour objet des compositions comprenant ces composés, utiles pour traiter des troubles de prolifération cellulaire, des troubles associés à l'activité de formes mutantes de p53, ou pour provoquer l'apoptose de cellules cancéreuses.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)