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1. (WO2007011618) QUINAZOLINE DERIVATIVES USEFUL IN CANCER TREATMENT
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/011618    International Application No.:    PCT/US2006/027105
Publication Date: 25.01.2007 International Filing Date: 13.07.2006
IPC:
C07D 239/94 (2006.01), C07D 239/90 (2006.01), C07D 401/12 (2006.01), C07D 403/12 (2006.01), C07D 405/12 (2006.01), C07D 409/12 (2006.01), C07D 409/14 (2006.01), C07D 413/12 (2006.01), A61K 31/517 (2006.01), A61P 35/00 (2006.01)
Applicants: SCHERING CORPORATION [US/US]; 2000 Galloping Hill Road, Kenilworth, New Jersey 07033-0530 (US) (For All Designated States Except US).
MALLAMS, Alan, K. [US/US]; (US) (For US Only).
DASMAHAPATRA, Bimalendu [US/US]; (US) (For US Only).
NEUSTADT, Bernard, R. [US/US]; (US) (For US Only).
DEMMA, Mark [US/US]; (US) (For US Only).
VACCARO, Henry, A. [US/US]; (US) (For US Only)
Inventors: MALLAMS, Alan, K.; (US).
DASMAHAPATRA, Bimalendu; (US).
NEUSTADT, Bernard, R.; (US).
DEMMA, Mark; (US).
VACCARO, Henry, A.; (US)
Agent: BANERJEE, Krishna, G.; Schering-Plough Corporation, 2000 Galloping Hill Road, Patent Dept. K-6-1 1990, Kenilworth, New Jersey 07033-0530 (US)
Priority Data:
60/700,056 15.07.2005 US
Title (EN) QUINAZOLINE DERIVATIVES USEFUL IN CANCER TREATMENT
(FR) DERIVEES DE QUINAZOLINE UTILES POUR LE TRAITEMENT DU CANCER
Abstract: front page image
(EN)The present invention provides compounds of Formula (I) (wherein R1, R2, R3, L, and X are as defined herein), or a pharmaceutically acceptable salt, solvate or ester thereof. The present invention also provides compositions comprising these compounds that are useful for treating cellular proliferative diseases, disorders associated with activity of mutants of p53, or in causing apoptosis of cancer cells.
(FR)Composés de formule I (R1, R2, R3, L, et X sont tels que définis dans la description), y compris un sel, solvate ou ester correspondant. Egalement, compositions renfermant ces composés, utiles pour traiter des maladies liées à la prolifération cellulaire, ou des troubles associés à l'activité de mutants de p53, ou pour induire l'apoptose des cellules cancéreuses.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)