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1. (WO2007011571) DIGITIZING BIOLOGY
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/011571 International Application No.: PCT/US2006/026777
Publication Date: 25.01.2007 International Filing Date: 11.07.2006
Chapter 2 Demand Filed: 09.01.2007
IPC:
A61B 5/00 (2006.01) ,G01J 3/00 (2006.01) ,G01J 5/02 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
B
DIAGNOSIS; SURGERY; IDENTIFICATION
5
Measuring for diagnostic purposes; Identification of persons
G PHYSICS
01
MEASURING; TESTING
J
MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRA-RED, VISIBLE OR ULTRA-VIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
3
Spectrometry; Spectrophotometry; Monochromators; Measuring colours
G PHYSICS
01
MEASURING; TESTING
J
MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRA-RED, VISIBLE OR ULTRA-VIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
5
Radiation pyrometry
02
Details
Applicants:
CHEMIMAGE CORPORATION [US/US]; 7301 Penn Avenue Pittsburgh, PA 19103, US (AllExceptUS)
MAIER, John, S. [US/US]; US (UsOnly)
TREADO, Patrick, J. [US/US]; US (UsOnly)
COHEN, Jeffrey [US/US]; US (UsOnly)
NEISS, Jason [US/US]; US (UsOnly)
Inventors:
MAIER, John, S.; US
TREADO, Patrick, J.; US
COHEN, Jeffrey; US
NEISS, Jason; US
Agent:
GOLUB, Daniel, H.; 1701 Market Street Philadelphia, PA 19103, US
Priority Data:
60/699,46115.07.2005US
Title (EN) DIGITIZING BIOLOGY
(FR) NUMERISATION DE DONNEES BIOLOGIQUES
Abstract:
(EN) A method and apparatus for determining the progress of a disease. A pre-determined vector space is determined where the vector space mathematically describes a reference set of wavelength resolved data at a plurality of time intervals. A sample containing at least one cell is irradiated with light. Target data is collected where the target data corresponds to at least one of light emitted from or scattered by the sample and includes a plurality of spatially accurate wavelength resolved measurements of light. The target data is transformed into the pre-determined vector space for each spatially accurate wavelength resolved measurement of light. A distribution of transformed points is analyzed in the plurality of pre-determined vector space. Based on the analysis, a transition of a disease condition of the sample is classified.
(FR) La présente invention se rapporte à un procédé et à un appareil permettant de déterminer l'évolution d'une maladie. Le procédé selon l'invention consiste: à déterminer un espace vectoriel prédéterminé, lequel décrit mathématiquement un jeu de référence de données résolues en longueur d'onde à une pluralité d'intervalles temporels ; à irradier de lumière un échantillon contenant au moins une cellule ; à collecter des données cibles, lesquelles correspondent à une lumière qui est soit émise par l'échantillon soit diffusée de ce dernier, et contiennent une pluralité de mesures de lumière résolues en longueur d'onde spatialement correctes ; à transformer les données cibles en l'espace vectoriel prédéterminé pour chaque mesure de lumière résolue en longueur d'onde spatialement correcte; à analyser une distribution de points transformés dans l'espace vectoriel prédéterminé ; à classer, sur la base de ladite analyse, une transition vers un état pathologique de l'échantillon.
front page image
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP1906814CA2614319