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1. (WO2007011473) MODIFIED RELEASE TICLOPIDINE COMPOSITIONS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/011473 International Application No.: PCT/US2006/022597
Publication Date: 25.01.2007 International Filing Date: 09.06.2006
IPC:
A61K 9/26 (2006.01) ,A61K 9/14 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
20
Pills, lozenges or tablets
22
Sustained or differential release type
26
Discrete particles in supporting matrix
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
14
Particulate form, e.g. powders
Applicants:
ELAN CORPORATION, PLC; Treasury Building Lower Grand Canal Street Dublin 2, IE (AllExceptUS)
LIVERSIDGE, Gary [US/US]; US (UsOnly)
JENKINS, Scott [US/US]; US (UsOnly)
STARK, Paul [GB/IE]; IE (UsOnly)
FANNING, Niall [IE/IE]; IE (UsOnly)
REKHI, Gurvinder [US/US]; US (UsOnly)
DEVANE, John [IE/IE]; IE (UsOnly)
Inventors:
LIVERSIDGE, Gary; US
JENKINS, Scott; US
STARK, Paul; IE
FANNING, Niall; IE
REKHI, Gurvinder; US
DEVANE, John; IE
Agent:
SLAVITT, Joshua R.; Synnestvedt & Lechner Llp 2600 Aramark Tower 1101 Market Street Philadelphia, PA 19107-2950, US
Priority Data:
11/372,85710.03.2006US
60/686,93112.06.2005US
Title (EN) MODIFIED RELEASE TICLOPIDINE COMPOSITIONS
(FR) COMPOSITIONS DE TICLOPIDINE À DIFFUSION MODIFIÉE
Abstract:
(EN) The invention relates to a multiparticulate modified release composition that, upon administration to a patient, delivers ticlopidine in a bimodal, multimodal or continuous manner. The multiparticulate modified release composition comprises a first component and at least one subsequent component, the first component comprising a first population of active ingredient containing particles and the at least one subsequent component comprising a second population of active ingredient containing particles. The invention also relates to a solid oral dosage form containing such multiparticulate modified release composition, and to methods for inhibiting platelet aggregation, inhibiting blood clotting, and reducing risk of stroke in a patient.
(FR) Cette invention se rapporte à une composition à diffusion modifiée multiparticulaire qui, une fois administrée à un patient, diffuse de la ticlopidine de manière bimodale, multimodale ou continue. La composition à diffusion modifiée multiparticulaire comprend un premier composant et au moins un composant secondaire, le premier composant comprenant une première population d'ingrédients actifs contenant des particules et au moins un composant secondaire comprenant une seconde population d'ingrédients actifs contenant des particules. Cette invention a également trait à une forme de dosage oral solide contenant cette composition à diffusion modifiée multiparticulaire et aux méthodes d'inhibition de l'agrégation plaquettaire, d'inhibition de la coagulation du sang et de réduction du risque d'accident cérébrovasculaire chez un patient.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP1901718JP2009516636US20090297597CA2611938