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1. (WO2007011412) DIAGNOSIS AND PROGNOSIS OF INFECTIOUS DIESEASE CLINICAL PHENOTYPES AND OTHER PHYSIOLOGIC STATES USING HOST GENE EXPRESION BIOMARKERS IN BLOOD
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/011412 International Application No.: PCT/US2005/040196
Publication Date: 25.01.2007 International Filing Date: 07.11.2005
IPC:
C12Q 1/68 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
Applicants:
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE NAVY [US/US]; Naval Research Laboratory 4555 Overlook Ave, SW Code 1008.2 Washington, DC 20375, US (AllExceptUS)
AGAN, Brian, K. [US/US]; US (UsOnly)
HANSON, Eric, H. [US/US]; US (UsOnly)
JENKINS, Michael, J [US/US]; US (UsOnly)
LIN, Baochuan [US/US]; US (UsOnly)
OLSEN, Chris, C. [US/US]; US (UsOnly)
ROWLEY, Robb, K. [US/US]; US (UsOnly)
STENGER, David, A. [US/US]; US (UsOnly)
THACH, Dzung, C. [US/US]; US (UsOnly)
TIBBETTS, Clark, J. [US/US]; US (UsOnly)
WALTER, Elizabeth, A. [US/US]; US (UsOnly)
LIU, Jinny, Lin [US/US]; US (UsOnly)
Inventors:
AGAN, Brian, K.; US
HANSON, Eric, H.; US
JENKINS, Michael, J; US
LIN, Baochuan; US
OLSEN, Chris, C.; US
ROWLEY, Robb, K.; US
STENGER, David, A.; US
THACH, Dzung, C.; US
TIBBETTS, Clark, J.; US
WALTER, Elizabeth, A.; US
LIU, Jinny, Lin; US
Agent:
KARASEK, John, J.; US Naval Research Laboratory 4555 Overlook Ave, SW Washington, DC 20375, US
Priority Data:
60/626,50005.11.2004US
Title (EN) DIAGNOSIS AND PROGNOSIS OF INFECTIOUS DIESEASE CLINICAL PHENOTYPES AND OTHER PHYSIOLOGIC STATES USING HOST GENE EXPRESION BIOMARKERS IN BLOOD
(FR) DIAGNOSTIC ET PRONOSTIC DE PHENOTYPES CLINIQUES DE MALADIES INFECTIEUSES ET D'AUTRES ETATS BIOLOGIQUES AU MOYEN DE MARQUEURS DE L'EXPRESSION GENIQUE HOTES DANS LE SANG
Abstract:
(EN) The present invention provides a specific set of gene expression markers from peripheral blood leukocytes that are indicative of a host response to exposure, response, and recovery infectious pathogen infections. The present invention further provides methods for identifying the specific set of gene expression markers, methods of monitoring disease progression and treatment of infectious pathogen infections, methods of prognosing the onset of an infectious pathogen infection, and methods of diagnosing an infectious pathogen infection and identifying the pathogen involved.
(FR) La présente invention concerne un ensemble spécifique de marqueurs d'expression génique issus des leucocytes du sang périphérique qui indiquent une réponse d'hôte à l'exposition, la réaction et la guérison d'infections par des pathogènes infectieux. L'invention se rapporte en outre à des procédés qui permettent d'identifier l'ensemble spécifique de marqueurs d'expression génique précité, à des procédés qui permettent de surveiller la progression de la maladie et le traitement d'infections par des pathogènes infectieux, et à des procédés qui permettent de diagnostiquer une infection par un pathogène infectieux et d'identifier le pathogène impliqué.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
NO20072853KR1020070085817EP1807540JP2008518626CN101218355CA2586374
NZ555575AU2005334466IN1985/KOLNP/2007