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1. (WO2007011410) PRODUCTION OF AN ASPOROGENIC STRAIN OF BACILLUS LICHENIFORMIS AND ITS USE FOR THE PRODUCTION OF KERATINASE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/011410 International Application No.: PCT/US2005/039583
Publication Date: 25.01.2007 International Filing Date: 28.10.2005
IPC:
C12N 9/56 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9
Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
14
Hydrolases (3.)
48
acting on peptide bonds, e.g. thromboplastin, leucine aminopeptidase (3.4)
50
Proteinases
52
derived from bacteria
54
bacteria being Bacillus
56
Bacillus subtilis or Bacillus licheniformis
Applicants:
NORTH CAROLINA STATE UNIVERSITY [US/US]; 920 Main Campus Drive, CB 8210 Venture Building II, Suite 400 Raleigh, North Carolina 27606, US (AllExceptUS)
SHIH, Jason C.H. [US/US]; US (UsOnly)
Inventors:
SHIH, Jason C.H.; US
Agent:
MYERS BIGEL SIBLEY & SAJOVEC, P.A.; P.O. Box 37428 Raleigh, North Carolina 27627, US
Priority Data:
60/623,75929.10.2004US
Title (EN) PRODUCTION OF AN ASPOROGENIC STRAIN OF BACILLUS LICHENIFORMIS AND ITS USE FOR THE PRODUCTION OF KERATINASE
(FR) DEVELOPPEMENT D'UN BACILLUS LICHENIFORMIS ASPOROGENE ET PRODUCTION DE KERATINASE A PARTIR DE CELUI-CI
Abstract:
(EN) A recombinant bacteria and methods of making and using the same are provided. The recombinant bacteria is a recombinant Bacillus having an inactive endogenous spoIIAC gene, with said recombinant Bacillus producing greater quantities of keratinase than a corresponding wild-type Bacillus that does not have said inactive endogenous spoIIAC gene inserted therein. The Bacillus can be Bacillus licheniformis or Bacillus subtilis. The recombinant Bacillus can be a sporulation-deficient Bacillus. A feed additive including keratinase derived from the recombinant Bacillus having an inactive endogenous spoIIAC gene and methods of inactivating an infectious prion protein are also provided.
(FR) L'invention concerne des bactéries recombinantes ainsi que des procédés de production et d'utilisation de celles-ci. La bactérie recombinante est un Bacillus recombinant présentant un gène spollAC endogène inactif, ledit Bacillus recombiné produisant des quantités supérieures de kératinase par rapport à un Bacillus de type sauvage correspondant qui ne présente pas ledit gène spollAC endogène inactif inséré à l'intérieur. Le Bacillus peut être un Bacillus licheniformis ou un Bacillus subtilis. Le Bacillus recombiné peut être un Bacillus déficient dans sa sporulation. L'invention concerne également un additif alimentaire comprenant de la kératinase dérivée du Bacillus recombiné présentant un gène spollAC endogène inactif ainsi que des procédés d'inactivation d'une protéine prion infectieuse.
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Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)