WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2007011392) CRYSTAL STRUCTURE OF DOMAIN 111 OF WEST NILE VIRUS ENVELOPE PROTEIN-FAB FRAGMENT OF NEUTRALIZING ANTIBODY COMPLEX
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/011392    International Application No.:    PCT/US2005/036790
Publication Date: 25.01.2007 International Filing Date: 14.10.2005
IPC:
C12Q 1/68 (2006.01), C12P 21/06 (2006.01)
Applicants: WASHINGTON UNIVERSITY [US/US]; One Brookings Drive, St. Louis, MO 63130 (US) (For All Designated States Except US).
FREMONT, Daved, H. [US/US]; (US) (For US Only).
NYBAKKEN, Grant [US/US]; (US) (For US Only).
DIAMOND, Michael [US/US]; (US) (For US Only)
Inventors: FREMONT, Daved, H.; (US).
NYBAKKEN, Grant; (US).
DIAMOND, Michael; (US)
Agent: MEYER, Mercedes K.; Drinker Biddle & Reath LLP, 1500 K Street, N.W., Suite 1100, Washington, DC 20005-1209 (US)
Priority Data:
60/619,273 14.10.2004 US
60/702,803 26.07.2005 US
Title (EN) CRYSTAL STRUCTURE OF DOMAIN 111 OF WEST NILE VIRUS ENVELOPE PROTEIN-FAB FRAGMENT OF NEUTRALIZING ANTIBODY COMPLEX
(FR) CRISTAUX ET STRUCTURE DU DOMAINE III DE LA PROTEINE ENVELOPPE VIRUS DU NIL OCCIDENTAL EN ASSOCIATION AVEC UN FRAGMENT FAB D'UN ANTICORPS NEUTRALISANT
Abstract: front page image
(EN)The present invention provides crystalline forms of domain III of the West Nile Virus (“WNV”) envelope protein in complex with a Fab fragment of a neutralizing antibody, methods of obtaining such crystals and high-resolution structures and atomic structure coordinates. The crystals of the invention and the atomic structural information are useful for solving crystal and solution structures of related and unrelated proteins, and for screening for, identifying or designing compounds or antibodies that bind to, modulate a biological activity of, or neutralize infection mediated by flaviviral envelope proteins.
(FR)La présente invention concerne des formes cristallines du domaine III de la protéine enveloppe du virus du Nil occidental (VNO) en complexe avec un fragment Fab d'un anticorps neutralisant, des procédés destinés à obtenir ces cristaux ainsi que des structures de haute résolution et des coordonnées de structure atomique. Les cristaux de l'invention et les informations de structure atomique sont utiles pour résoudre des structures cristallines et des structures de solution de protéines apparentées et non apparentées, et pour cribler, identifier ou élaborer des composés ou des anticorps qui se lient aux protéines enveloppes flavivirales, qui modulent une activité biologique de ces protéines ou qui neutralisent une infection médiée par celles-ci.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)