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1. (WO2007011217) METHOD OF CONJUGATING THERAPEUTIC COMPOUNDS TO CELL TARGETING MOIETIES VIA METAL COMPLEXES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/011217 International Application No.: PCT/NL2006/000383
Publication Date: 25.01.2007 International Filing Date: 20.07.2006
IPC:
A61K 47/48 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
48
the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
Applicants:
Kreatech Biotechnology B.V. [NL/NL]; Vlierweg 20 NL-1032 LG Amsterdam, NL (AllExceptUS)
HEETEBRIJ, Robert, Jochem [NL/NL]; NL (UsOnly)
KOK, Robbert, Jan [NL/NL]; NL (UsOnly)
TALMAN, Eduard, Gerhard [NL/NL]; NL (UsOnly)
POELSTRA, Klaas [NL/NL]; NL (UsOnly)
MOLEMA, Grietje [NL/NL]; NL (UsOnly)
Inventors:
HEETEBRIJ, Robert, Jochem; NL
KOK, Robbert, Jan; NL
TALMAN, Eduard, Gerhard; NL
POELSTRA, Klaas; NL
MOLEMA, Grietje; NL
Agent:
VAN LOON, C.J.J.; Johan De Wittlaan 7 NL-2517 JR Den Haag, NL
Priority Data:
05076682.320.07.2005EP
Title (EN) METHOD OF CONJUGATING THERAPEUTIC COMPOUNDS TO CELL TARGETING MOIETIES VIA METAL COMPLEXES
(FR) PROCEDE PERMETTANT DE CONJUGUER DES COMPOSES THERAPEUTIQUES A DES DISPOSITIFS DE CIBLAGE DE CELLULES PAR LE BIAIS DE COMPLEXES METALLIQUES
Abstract:
(EN) The present invention relates to a cell-targeting complex comprising a targeting moiety and a deliverable compound, wherein said targeting moiety and said deliverable compound are joined by means of a (transition) metal ion complex having at least a first reactive moiety for forming a coordination bond with a reactive site of said targeting moiety and having at least a second reactive moiety for forming a coordination bond with a reactive site of said deliverable compound, and wherein said deliverable compound is a therapeutic compound.
(FR) L'invention concerne un complexe de ciblage de cellules comprenant un fragment de ciblage et un composé administrable, ledit fragment de ciblage et ledit composé administrable étant liés par un complexe d'ions métalliques (de transition) ayant au moins un premier fragment réactif pour former une liaison de coordination avec un site réactif dudit fragment de ciblage et ayant au moins un second fragment réactif pour former une liaison de coordination avec un site réactif dudit composé administrable, ce composé administrable étant un composé thérapeutique.
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Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP1907011JP2009501791US20110104103CA2616116AU2006270566