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Machine translation
1. (WO2007011216) BIFUNCTIONAL PROTEIN ANCHORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/011216    International Application No.:    PCT/NL2006/000382
Publication Date: 25.01.2007 International Filing Date: 20.07.2006
Chapter 2 Demand Filed:    02.04.2007    
IPC:
C07K 14/335 (2006.01), A61K 39/39 (2006.01), A61K 39/385 (2006.01), A61P 31/00 (2006.01), A61P 33/00 (2006.01), A61P 35/00 (2006.01), A61P 37/00 (2006.01)
Applicants: APPLIED NANOSYSTEMS B.V. [NL/NL]; Postbus 100, NL-9700 AC Groningen (NL) (For All Designated States Except US).
LEENHOUTS, Cornelis, Johannes [NL/NL]; (NL) (For US Only).
VAN ROOSMALEN, Maarten, Leonardus [NL/NL]; (NL) (For US Only).
BOSMA, Tjibbe [NL/NL]; (NL) (For US Only)
Inventors: LEENHOUTS, Cornelis, Johannes; (NL).
VAN ROOSMALEN, Maarten, Leonardus; (NL).
BOSMA, Tjibbe; (NL)
Agent: VAN LOON, C.J.J.; Johan De Wittlaan 7, NL-2517 JR Den Haag (NL)
Priority Data:
05076680.7 20.07.2005 EP
Title (EN) BIFUNCTIONAL PROTEIN ANCHORS
(FR) ANCRAGES DE PROTEINES BIFONCTIONNELS
Abstract: front page image
(EN)The invention relates to the areas of immunology and vaccine delivery. More specifically, it relates to a bacterial vaccine delivery technology with built-in immunostimulatory properties which allows the immobilization of any antigen of interest, without prior antigen modification. Provided is an antigen-loaded immunogenic carrier complex comprising at least one bifunctional polypeptide attached to an immunogenic carrier, said bifunctional polypeptide comprising a peptidoglycan binding domain (PBD) through which the polypeptide is attached to said carrier, fused to an antigen binding domain (ABD) to which at least one antigen of interest is bound. Also provided is a pharmaceutical (e.g. vaccine) composition comprising an antigen-loaded immunogenic carrier complex of the invention.
(FR)L'invention concerne les domaines de l'immunologie et de l'administration de vaccins. Plus précisément, l'invention concerne une technologie d'administration de vaccin bactérien à propriétés immunostimulatoires intégrées permettant d'immobiliser un antigène quelconque étudié, sans modification préalable de l'antigène. L'invention concerne également un complexe d'excipient immunogène chargé d'antigènes comprenant au moins un polypeptide bifonctionnel fixé sur un excipient immunogène, le polypeptide bifonctionnel comprenant un domaine de liaison au peptidoglycane (PBD) par le biais duquel le polypeptide est fixé sur l'excipient, fusionné à un domaine de liaison aux antigènes (ABD) auquel au moins un antigène étudié est lié. L'invention concerne enfin une composition pharmaceutique (par exemple, un vaccin) comprenant un complexe d'excipient immunogène chargé d'antigènes selon l'invention.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)